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Figure 3 | Clinical Epigenetics

Figure 3

From: Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes

Figure 3

Differences in the genomic distribution of age-modified CpG sites. (A) Frequency of age-modified CpG sites according to the proximity to a CpG island (CGI). (B) Frequency of age-modified CpG sites according to regulatory annotations. (C) Frequency of age-modified CpG sites according to the gene location. TSS = transcriptional start site; UTR = untranslated region; age-methylated CpGs mapped to 537 gene locations and age-demethylated CpGs to 769 gene locations. (D) Frequency of age-modified CpG sites binned by absolute distance to the nearest TSS. (E) Frequency of age-modified CpG sites according to their location in relation to the nearest TSS (upstream/downstream).

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