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Figure 9 | Clinical Epigenetics

Figure 9

From: The role of microRNA-1246 in the regulation of B cell activation and the pathogenesis of systemic lupus erythematosus

Figure 9

The regulation of miR-1246 expression by AKT-P53 signaling pathway in B cells from SLE patients. AKT protein phosphorylation, P53 protein levels, and miR-1246 expression were detected in AKT inhibitor-treated SLE B cells compared with PBS-treated SLE B cells. (A-C) AKT phosphorylation was markedly decreased, while P53 protein level and miR-1246 expression were sharply upregulated in AKT inhibitor-treated SLE B cells compared with PBS-treated SLE B cells. The Western blot image is a representative image. Data are presented as the mean ± SD of the same experiments performed in three active SLE patients. (**P < 0.01).

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