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Table 2 Correlation between methylation of all studied CGs and serum IGF1 concentration (SDS) ( N = 184 )

From: The IGF1 P2 promoter is an epigenetic QTL for circulating IGF1 and human growth

 

Serum IGF1 (SDS)

Discovery cohort

Replication cohort

Total

R

P

R

P

R

P

P1 promoter

CG-1044

−0.05

1

0.08

1

0.03

1

CG-960

0.08

1

0.07

1

0.01

1

CG-919

0.07

1

−0.22

0.6

−0.10

1

CG-631

−0.18

0.7

−0.07

1

−0.10

1

CG-611

−0.27

0.06

−0.33

0.02

−0.25

9.10 -3

CG-491

−0.05

1

−0.11

1

−0.07

1

CG-414

0.06

1

0.21

0.6

−0.15

0.5

CG-308

0.00

1

0.04

1

0.03

1

CG-225

0.09

1

0.09

1

0.04

1

P2 promoter

CG-232

−0.19

0.46

−0.29

0.08

−0.24

8.10 −3

CG-224

−0.24

0.14

−0.05

1

−0.19

9.10 −2

CG-218

−0.23

0.17

−0.22

0.5

−0.24

0.01

CG-207

−0.14

1

0.09

1

−0.14

0.5

CG-137

−0.34

5.10 −3

−0.28

0.11

−0.32

10 −4

CG-108

−0.29

0.08

−0.28

0.05

−0.30

4.10 −4

Average*

−0.30

0.017

−0.25

0.17

−0.29

6.10 −4

CG-77

−0.23

0.25

−0.09

1

−0.17

0.3

CG + 97

−0.22

0.29

−0.04

1

−0.12

1

  1. To account for multiple CG testing, we used Bonferroni correction of the P values studied. P values greater than 1 are equated to 1. *Values for the averaged 6 CGs from −108 to −232.
  2. Italicized letters and numbers indicate significant correlation.
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Clinical Epigenetics

ISSN: 1868-7083

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