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Table 2 Correlation between methylation of all studied CGs and serum IGF1 concentration (SDS) ( N = 184 )

From: The IGF1 P2 promoter is an epigenetic QTL for circulating IGF1 and human growth

  Serum IGF1 (SDS)
Discovery cohort Replication cohort Total
R P R P R P
P1 promoter CG-1044 −0.05 1 0.08 1 0.03 1
CG-960 0.08 1 0.07 1 0.01 1
CG-919 0.07 1 −0.22 0.6 −0.10 1
CG-631 −0.18 0.7 −0.07 1 −0.10 1
CG-611 −0.27 0.06 −0.33 0.02 −0.25 9.10 -3
CG-491 −0.05 1 −0.11 1 −0.07 1
CG-414 0.06 1 0.21 0.6 −0.15 0.5
CG-308 0.00 1 0.04 1 0.03 1
CG-225 0.09 1 0.09 1 0.04 1
P2 promoter CG-232 −0.19 0.46 −0.29 0.08 −0.24 8.10 −3
CG-224 −0.24 0.14 −0.05 1 −0.19 9.10 −2
CG-218 −0.23 0.17 −0.22 0.5 −0.24 0.01
CG-207 −0.14 1 0.09 1 −0.14 0.5
CG-137 −0.34 5.10 −3 −0.28 0.11 −0.32 10 −4
CG-108 −0.29 0.08 −0.28 0.05 −0.30 4.10 −4
Average* −0.30 0.017 −0.25 0.17 −0.29 6.10 −4
CG-77 −0.23 0.25 −0.09 1 −0.17 0.3
CG + 97 −0.22 0.29 −0.04 1 −0.12 1
  1. To account for multiple CG testing, we used Bonferroni correction of the P values studied. P values greater than 1 are equated to 1. *Values for the averaged 6 CGs from −108 to −232.
  2. Italicized letters and numbers indicate significant correlation.