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Table 5 The association of TNFα 5′CGI methylation status and asthma in children

From: Effects of phthalate exposure on asthma may be mediated through alterations in DNA methylation

  Asthma Non-asthma Subjects OR Adjusted OR b
( N = 56) ( N = 200) ( N = 256) (95% CIs) (95% CIs)
Lower methylated TNFα 5′CGIa 35(62.5) 93(46.5) 128(50.0) 1.92(1.04 to 3.52)* 2.15(1.01 to 4.62)*
Higher methylated 21(37.5) 107(53.5) 128(50.0) 1 1
  1. a TNFα methylation status was dichotomized into lower and higher methylated group with cutoff value of median of promoter methylation percentage; bAdjustment for gender, age, prematurity, maternal history of atopy, maternal education, and environmental tobacco smoke exposure. *P<0.05.