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Table 5 The association of TNFα 5′CGI methylation status and asthma in children

From: Effects of phthalate exposure on asthma may be mediated through alterations in DNA methylation

 

Asthma

Non-asthma

Subjects

OR

Adjusted OR b

( N = 56)

( N = 200)

( N = 256)

(95% CIs)

(95% CIs)

Lower methylated TNFα 5′CGIa

35(62.5)

93(46.5)

128(50.0)

1.92(1.04 to 3.52)*

2.15(1.01 to 4.62)*

Higher methylated

21(37.5)

107(53.5)

128(50.0)

1

1

  1. a TNFα methylation status was dichotomized into lower and higher methylated group with cutoff value of median of promoter methylation percentage; bAdjustment for gender, age, prematurity, maternal history of atopy, maternal education, and environmental tobacco smoke exposure. *P<0.05.