Effects of phthalate exposure on asthma may be mediated through alterations in DNA methylation

Clinical Epigenetics

Table 3 The association of log-transformed urine phthalate levels and standardized regression coefficients βeta for TNFα methylation

Urine phthalate metabolites ^b	Ln-MEP	P value	Ln-MBP	P value	Ln-MBzP	P value	Ln-5OH-MEHP	P value
TNFα (Met%)
Crude β	−0.009	0.887	−0.057	0.367	−0.154	0.014*	−0.175	0.005*
Adjusted β ^a	−0.045	0.508	−0.044	0.534	−0.144	0.032*	−0.138	0.040*

MEP, monoethyl phthalate; MBP, monobutyl phthalate; MBzP, monobenzyl phthalate; 5OH-MEHP, mono(2-ethyl-5-hydroxyhexyl)phthalate; Met%, methylation percentage. ^aAdjustment for urine creatinine, white blood cell proportion, gender, age, maternal education, and environmental tobacco smoke exposure; ^bThe main urine phthalate metabolite levels measured in this study included MEP, MBP, MBzP, and 5OH-MEHP.*P < 0.05.

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