Average percentages of hypermethylated miRNAs and box-and-whisker plots. (A) Average percentages of hypermethylated miRNAs out of 7 per endometrial sample. The set of miRNAs include miR-572, 129-2, 663, 375-I, 345, 132, and 34a. Specimens of normal endometrium (N) and endometrial hyperplasias of increasing severity (SH, CH, and CAH) are displayed. Sporadic and Lynch syndrome-associated cases are shown separately (see the ‘Methods’ section for sample sizes). (B) Box-and-whisker plots for the distribution of Dm values for 129-2 in normal endometrium and endometrial hyperplasias. Sporadic and Lynch syndrome-associated cases were combined since they revealed similar distributions when analyzed individually.