Figure 3

Box-and-whisker plots of miRNA-specific distributions of methylation dosage ratios. The Dm values in paired tumor and normal DNAs from each patient group are shown (please see the key for details). The horizontal line inside the box denotes the median, the upper and lower edges are the 75th and 25th percentiles, and the bars indicate the highest and lowest Dm values. P values are based on t-test for paired samples or Wilcoxon signed rank test. The miRNAs 129-2, 345, and 132 are shown in bold because their methylation pattern was considered the most promising for further studies.