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Figure 6 | Clinical Epigenetics

Figure 6

From: Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients

Figure 6

The methylation level in each cytosine in sperm DNA was analyzed by pyrosequencing. (A) DNA methylation in 12 cytosines (CpG) in H4K12ac-associated NSD1 promoter in fertile donors and subfertile patients. (B) Averaged DNA methylation in 1 to 4 CpGs and 5 to 12 CpGs of NSD1 promoter in fertile and subfertile men. (C) DNA hypermethylation in 12 CpGs in sperm-specific protamine promoter. (D) Averaged methylation from 12 CpGs in protamine promoters showing no significant difference between fertile and subfertile sperm.

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