Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites

Table 1 Association of DMRs and gene expression changes using the projection test

DNAm	Gene expression	Enriched/depleted	P value
SA-hyperFibro1	Downregulated genes	Enriched	2.44E-08
SA-hyperFibro2	Downregulated genes	Enriched	1.88E-05
SA-hyperMSC	Downregulated genes	Enriched	1.30E-07
SA-hyperFibro1	Upregulated genes	Enriched	0.011
SA-hyperFibro2	Upregulated genes	Enriched	2.07E-09
SA-hyperMSC	Upregulated genes	Enriched	0.006
SA-hypoFibro1	Upregulated genes		No significance
SA-hypoFibro2	Upregulated genes		No significance
SA-hypoMSC	Upregulated genes		No significance
SA-hypoFibro1	Downregulated genes	Depleted	0.0008
SA-hypoFibro2	Downregulated genes		No significance
SA-hypoMSC	Downregulated genes		No significance

ISSN: 1868-7083