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Figure 6 | Clinical Epigenetics

Figure 6

From: Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites

Figure 6

Scheme of chromosomal changes in replicative senescence. Nuclear size increases; telomeres shorten and shift towards the nuclear center; DNA hypermethylation is rather observed in regions with the repressive histone mark H3K27me3 and with the activating histone marks H3K4me3 and H3K4me1, whereas hypomethylation is associated with H3K9me3 and LADs; gene expression changes are particularly observed in hypermethylated regions. DNAm changes and differentially expressed genes coincide with binding motifs for specific TFs.

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Clinical Epigenetics

ISSN: 1868-7083

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