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Figure 5 | Clinical Epigenetics

Figure 5

From: Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites

Figure 5

Transcription factor binding sites in differentially methylated regions. Analysis of transcription factor binding sites was performed in DMRs and promoter regions of up-/downregulated genes. The heatmap shows the -log10 P value for motifs enriched in at least one DMR signature (Fisher’s Exact test followed by Benjamin Hochberg multiple test correction, adj. P value < 0.05) (A). Motifs for the five most significant transcription factors are depicted (B). Subsequently, binding sites in promoter regions of either up- or downregulated genes were analyzed, and motifs common in both lists are marked in bold (Fisher’s Exact test followed by Benjamin Hochberg multiple test correction, adj. P value < 0.05) (C).

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