Figure 5From: Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites Transcription factor binding sites in differentially methylated regions. Analysis of transcription factor binding sites was performed in DMRs and promoter regions of up-/downregulated genes. The heatmap shows the -log10 P value for motifs enriched in at least one DMR signature (Fisher’s Exact test followed by Benjamin Hochberg multiple test correction, adj. P value < 0.05) (A). Motifs for the five most significant transcription factors are depicted (B). Subsequently, binding sites in promoter regions of either up- or downregulated genes were analyzed, and motifs common in both lists are marked in bold (Fisher’s Exact test followed by Benjamin Hochberg multiple test correction, adj. P value < 0.05) (C).Back to article page