Comparison of CpG site methylation of cord-blood-cell-associated EOPE and normal mothers. Distributions of all CpG site categories on the Illumina HumanMethylation450 BeadChip array (background), all differentially methylated CpG sites, hypomethylated CpG sites, and hypermethylated CpG sites. Categories with significantly different proportions (P < 0.05, Chi-square test) of differential CpG sites vs. expected background (all CpG sites) are labeled by (*). Differences in categorical proportions between hypomethylation and hypermethylation are labeled the same. (A) CpG site proportions by location relative to CpG isle regions. As stated in the “Results” section, six groups are categorized according to Illumina 450 K annotation, namely north shelf, north shore, CpG island, south shore, south shelf, and open sea. (B) CpG site proportions by functional location relative to gene regions. Seven groups are categorized, namely the 200 to 1,500 bp upstream of transcription starting site (TSS1500), the transcription starting site to 200 bp upstream interval (TSS200), 5′ UTR, first exon, gene body, 3′ UTR, and the rest for integenic regions. DM, differential methylation.