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Table 3 Clinical parameters of Malay subjects in epigenetic study

From: Increased DNA methylation of the SLC30A8 gene promoter is associated with type 2 diabetes in a Malay population

Group NGT T2D a T2D-DN T2D + DN P values b/c
N (men/women) 27 (19/8) 161 (81/80) 109 (49/60) 43 (25/18)  
Age (years) 57 ± 9 56 ± 9 55 ± 10 56 ± 10 NS/NS
Diabetes duration (years) - 12 ± 7 11 ± 8 11 ± 7 -/NS
BMI (kg/m2) 24 ± 4.0 28 ± 5 29 ± 5 27 ± 5 <0.001/NS
SBP (mm Hg) 132 ± 18 139 ± 24 135 ± 20 150 ± 33 NS/NS
DBP (mm Hg) 84 ± 14 80 ± 12 80 ± 12 83 ± 15 NS/NS
HbA1c (%) 5.7 ± 1.0 8.2 ± 2.0 8.1 ± 2.0 8.6 ± 2.4 <0.001/NS
Serum creatinine (μmol/l) 70.6 ± 17.1 126.4 ± 119.5 92.7 ± 72.9 215.8 ± 183.0 <0.005/<0.001
Urine creatinine (mmol/l) 12.3 ± 7.4 8.1 ± 6.8 9.7 ± 6.2 5.0 ± 3.52 <0.001/<0.001
ACR (mg/mmol) 0.86 ± 0.75 46.2 ± 127.1 1.19 ± 0.84 195.1 ± 206.1 <0.001/<0.001
eGFR (ml/min/1.73 m2) 102.8 ± 28.6 67.1 ± 28.0 76.5 ± 23.4 44.1 ± 26.0 <0.001/<0.001
SLC30A8 DNA methylation levels (95% CI) 80.1% (79.4 to 81.4) 82.9% (81.2 to 83.5) 82.7% (80.9 to 82.9) 83.6% (79.8 to 84.4) 0.014/0.632
  1. Data are expressed as means ± SD or 95% CI.
  2. NGT normal glucose tolerance, T2D type 2 diabetes, DN diabetic nephropathy, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, HbA1c glycosylated hemoglobin, ACR albumin creatinine ratio, eGFR estimated glomerular filtration rate.
  3. aThe patients with microalbuminuria were included.
  4. b P values were from tests of NGT vs. all T2D.
  5. c P values were from tests of T2D without DN vs. T2D with DN.