Table 3 Clinical parameters of Malay subjects in epigenetic study
Group | NGT | T2D a | T2D-DN | T2D + DN | P values b/c |
|---|---|---|---|---|---|
N (men/women) | 27 (19/8) | 161 (81/80) | 109 (49/60) | 43 (25/18) | |
Age (years) | 57 ± 9 | 56 ± 9 | 55 ± 10 | 56 ± 10 | NS/NS |
Diabetes duration (years) | - | 12 ± 7 | 11 ± 8 | 11 ± 7 | -/NS |
BMI (kg/m2) | 24 ± 4.0 | 28 ± 5 | 29 ± 5 | 27 ± 5 | <0.001/NS |
SBP (mm Hg) | 132 ± 18 | 139 ± 24 | 135 ± 20 | 150 ± 33 | NS/NS |
DBP (mm Hg) | 84 ± 14 | 80 ± 12 | 80 ± 12 | 83 ± 15 | NS/NS |
HbA1c (%) | 5.7 ± 1.0 | 8.2 ± 2.0 | 8.1 ± 2.0 | 8.6 ± 2.4 | <0.001/NS |
Serum creatinine (μmol/l) | 70.6 ± 17.1 | 126.4 ± 119.5 | 92.7 ± 72.9 | 215.8 ± 183.0 | <0.005/<0.001 |
Urine creatinine (mmol/l) | 12.3 ± 7.4 | 8.1 ± 6.8 | 9.7 ± 6.2 | 5.0 ± 3.52 | <0.001/<0.001 |
ACR (mg/mmol) | 0.86 ± 0.75 | 46.2 ± 127.1 | 1.19 ± 0.84 | 195.1 ± 206.1 | <0.001/<0.001 |
eGFR (ml/min/1.73 m2) | 102.8 ± 28.6 | 67.1 ± 28.0 | 76.5 ± 23.4 | 44.1 ± 26.0 | <0.001/<0.001 |
SLC30A8 DNA methylation levels (95% CI) | 80.1% (79.4 to 81.4) | 82.9% (81.2 to 83.5) | 82.7% (80.9 to 82.9) | 83.6% (79.8 to 84.4) | 0.014/0.632 |