Increased DNA methylation of the SLC30A8 gene promoter is associated with type 2 diabetes in a Malay population

Clinical Epigenetics

Table 2 Association of the SLC30A8 genetic polymorphisms with type 2 diabetes and diabetic nephropathy in a Malay population

SNP ID	Group	N	Genotypes			RAF	P value	Odds ratio
rs13266634			CC	CT	TT
	NGT	438	153	202	83	0.580	0.053	1.200 (0.997 to 1.443)
	All T2D^a	506	208	215	83	0.620	0.053	1.200 (0.997 to 1.443)
	T2D-DN	236	90	107	39	0.608	0.098	1.313 (0.950 to 1.815)
	T2D + DN	123	59	47	17	0.670	0.098	1.313 (0.950 to 1.815)
rs11558471			AA	AG	GG
	NGT	441	139	209	93	0.552	0.002	1.334 (1.110 to 1.602)
	All T2D^a	509	204	225	80	0.620	0.002	1.334 (1.110 to 1.602)
	T2D-DN	237	87	107	43	0.593	0.041	1.399 (1.013 to 1.932)
	T2D + DN	123	57	51	15	0.671	0.041	1.399 (1.013 to 1.932)

Tests were conducted with an additive model.
NGT normal glucose tolerance, T2D type 2 diabetes, DN diabetic nephropathy, RAF risk allele frequency.
^aThe patients with microalbuminuria were included.

ISSN: 1868-7083