Group | NGT | T2D a | T2D-DN | T2D + DN | P values b/c |
---|---|---|---|---|---|
N (men/women) | 476 (224/252) | 516 (260/256) | 239 (103/136) | 124 (66/58) | |
Age (years) | 42 ± 15 | 56 ± 10 | 55 ± 10 | 57 ± 10 | <0.001/NS |
Diabetes duration (years) | - | 14 ± 8 | 13 ± 8 | 14 ± 7 | -/NS |
BMI (kg/m2) | 26 ± 7.0 | 28 ± 5 | 29 ± 5 | 27 ± 5 | <0.001/0.059 |
SBP (mm Hg) | 127 ± 19 | 144 ± 25 | 139 ± 22 | 155 ± 31 | <0.001/0.001 |
DBP (mm Hg) | 80 ± 11 | 81 ± 12 | 80 ± 12 | 82 ± 13 | NS/NS |
FPG (mmol/l) | 4.87 ± 1.02 | 5.0 ± 1.22 | 4.76 ± 1.00 | 5.6 ± 1.05 | 0.028/0.035 |
HbA1c (%) | 5.4 ± 0.48 | 8.1 ± 2.17 | 7.6 ± 2.0 | 8.6 ± 2.4 | <0.001/<0.001 |
Serum creatinine (μmol/l) | 67.8 ± 33.7 | 122.3 ± 114.4 | 91.0 ± 72.9 | 207.3 ± 178.7 | <0.001/<0.001 |
Urine creatinine (mmol/l) | 12.3 ± 7.4 | 10.0 ± 6.8 | 11.4 ± 6.2 | 5.0 ± 3.52 | <0.001/<0.001 |
ACR (mg/mmol) | 3.32 ± 16.1 | 57.3 ± 175.4 | 1.10 ± 0.819 | 249.2 ± 311.5 | <0.001/<0.001 |
eGFR (ml/min/1.73 m2) | 112.9 ± 45.2 | 71.4 ± 38.2 | 81.0 ± 29.9 | 48.3 ± 35.2 | <0.001/<0.001 |