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Table 1 TOPS Family Study of Epigenetics (TFSE) cohort characteristics

From: An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome

 

Children and adolescents

Adults

(mean ± SD)

(mean ± SD)

Overweight and obese

32%

73%

Waist over MetS threshold

15%

52%

HOMA over MetS threshold

17%

32%

Hypertriglyceride

9%

20%

HDL-C over MetS threshold

51%

66%

MetS prevalence

NA

24%

Phenotype

Girls (n = 21)

Boys (n = 32)

Female (n = 85)

Male (n = 54)

  Weight, kg

56.35 ± 22.97

58.53 ± 25.15

82.98 ± 19.63

94.60 ± 23.36

  Height, cm

157.81 ± 13.09

159.69 ± 20.93

164.62 ± 6.87

177.31 ± 6.38

  BMI, kg/m2

22.10 ± 7.50

21.80 ± 5.70

30.75 ± 7.66

30.04 ± 6.76

  BMI%

55.61 ± 34.20

66.91 ± 26.16

NA

NA

  Waist circumference (WC), cm

68.15 ± 14.05

75.16 ± 18.15

93.87 ± 17.89

101.58 ± 16.92

  Subcutaneous fat (SubQF), g

361.49 ± 263.70

123.31 ± 95.00

319.34 ± 191.59

255.94 ± 131.42

  Visceral fat (VF), g

78.57 ± 24.02

43.66 ± 25.27

170.84 ± 149.50

265.24 ± 94.95

  VF/SubQF

0.32 ± 0.20

0.45 ± 0.20

0.56 ± 0.32

1.13 ± 0.40

  Total abdominal fat (TAF), g

440.05 ± 287.49

166.97 ± 114.39

490.18 ± 300.40

521.18 ± 204.41

  Fasting glucose (FG), mmol/l

82.28 ± 8.44

86.47 ± 8.54

84.26 ± 13.07

86.58 ± 15.37

  Fasting insulin (FI), pmol/l

14.81 ± 5.50

13.73 ± 5.69

16.12 ± 15.67

21.07 ± 22.91

  Insulin/glucose (IGR)

0.18 ± 0.06

0.16 ± 0.07

0.44 ± 1.66

0.52 ± 1.42

  Homeostasis model assessment insulin resistance (HOMA-IR)

3.03 ± 1.22

2.94 ± 1.32

3.53 ± 3.79

4.69 ± 5.15

  Triglycerides (TG), mmol/l

78.52 ± 28.11

78.00 ± 45.44

100.07 ± 52.44

117.69 ± 62.38

  Total Cholesterol (TC), mmol/l

152.76 ± 22.71

142.66 ± 25.78

193.06 ± 41.21

194.61 ± 38.77

  LDL-cholesterol (LDL-C), mmol/l

89.29 ± 24.62

85.75 ± 23.15

125.91 ± 38.39

133.82 ± 36.28

  HDL-cholesterol (HDL-C), mmol/l

46.95 ± 9.93

41.31 ± 9.50

46.29 ± 13.46

37.68 ± 9.93

  Systolic blood pressure (sBP), mmHg

105.50 ± 5.00

107.55 ± 10.42

127.34 ± 18.56

129.61 ± 13.97

  Diastolic blood pressure (dBP), mmHg

66.94 ± 8.30

69.45 ± 9.59

76.79 ± 10.89

81.94 ± 11.39

  Adiponectin, ng/ml

14.42 ± 5.96

10.45 ± 5.01

9.67 ± 5.52

7.95 ± 6.29

  Leptin, ng/ml

13.46 ± 11.26

6.66 ± 7.17

23.72 ± 14.15

9.85 ± 7.22