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Figure 3 | Clinical Epigenetics

Figure 3

From: An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome

Figure 3

DNA methylation changes with age in candidate genes related to obesity, MetS, and T2D. (A) Methylation of CpG site cg12782180 located in the TSS1500 of LEP with respect to age. (B) Methylation of CpG site cg08119452 located in the TSS1500 of OLFM4 with respect to age. (C) Methylation of CpG site cg05404236 located in the first exon of IRS2 with respect to age. (D) Methylation of CpG site cg24366557 located in the body of TFAP2B with respect to age. (E) Pyrosequencing validation of differential methylation with age identified by arrays. Scatter plot shows the overlay of age-associated methylation changes at CpG site cg14956327 (DDO) probed by the Illumina HM450 array (black dots) and pyrosequencing (green dots). Only children and adolescents samples were used in validation tests. The insert shows direct comparisons between the Illumina array and pyrosequencing validation.

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Clinical Epigenetics

ISSN: 1868-7083

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