Skip to main content

Table 2 Clinical characteristics of UHCW cohort

From: Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes

UHCW cohort Total Maternal B 12 (ng/L)
n= 91 >190 ( n= 55) ≤190 ( n= 36)
Age (years) 32.7 ± 0.62 33.0 ± 0.84 32.3 ± 0.93
BMI (kg/m2) 29.4 ± 0.65 28.4 ± 0.82 30.8 ± 1.07*
Triglycerides (mmol/L) 2.69 (2.62, 3.06) 2.49 (2.37, 2.93) 3.04 (2.82, 3.48)*
Cholesterol (mmol/L) 6.48 (6.31, 6.89) 6.23 (5.99, 6.72) 6.86 (6.51, 7.43)*
LDL cholesterol (mmol/L) 3.53 (3.46, 3.95) 3.29 (3.16, 3.82) 3.91 (3.67, 4.38)*
HDL cholesterol (mmol/L) 1.56 (1.53, 1.72) 1.61 (1.54, 1.80) 1.49 (1.42, 1.70)
HOMA-IR 2.14 (2.47, 3.39) 1.87 (2.18, 3.51) 2.65 (2.45, 3.68)
Leptin (μg/L) 30.8 (32.3, 40.8) 29.3 (29.7, 40.6) 33.1 (31.3, 45.5)
Folate (μg/L) 10.5 (10.9, 13.2) 11.7 (11.5, 14.6) 9.0 (8.5, 12.4)*
Homocysteine (μmol/L) 6.23 (6.02, 7.54) 5.50 (5.26, 6.18) 7.53 (6.69, 10.11)**
  1. Continuous variables are mean ± SEM or geometric mean (95% CI).
  2. P value compared to maternal B12 (>190 ng/L) group; *P < 0.05; **P < 0.001.