Skip to main content
Figure 3 | Clinical Epigenetics

Figure 3

From: Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes

Figure 3

Effect of vitamin B 12 on regulation of cholesterol biosynthesis. Protein and/or mRNA expression of genes regulating cholesterol biosynthesis in adipocytes. (A) SREBP-1, (B) SREBP-2, (C) SREBF1 and SREBF2, (D) LDLR, (E) INSIG1 and (F) StarD4. All experiments were performed as triplicates. Values are mean ± SEM. *P ≤ 0.05; **P ≤ 0.01, ***P ≤ 0.001, P value compared to control.

Back to article page