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Figure 2 | Clinical Epigenetics

Figure 2

From: Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes

Figure 2

Effect of vitamin B 12 on cholesterol biosynthesis. (A) Total cholesterol from adipocytes cultured in customised media: control (500 nM B12), LB (0.15 nM B12), and NoB (0 nM B12). Total cholesterol was normalized for protein content and expressed as percentage. mRNA expression of cholesterol biosynthesis genes in adipocytes. (B) HMGCS1, (C) HMGCR, (D) IDI1, (E) SQLE, and (F) SC4MOL. All experiments were performed as triplicates. Values are mean ± SEM. *P ≤ 0.05; **P ≤ 0.01, ***P ≤ 0.001, P value compared to control.

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Clinical Epigenetics

ISSN: 1868-7083

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