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Figure 3 | Clinical Epigenetics

Figure 3

From: Genome-wide DNA methylation analysis reveals estrogen-mediated epigenetic repression of metallothionein-1 gene cluster in breast cancer

Figure 3

Lower expression and higher methylation of MT1 gene cluster for ERα+ compared to ERα − and normal patient samples is observed in TCGA RNA-seq and our MBD-seq cohort, respectively. (A) A heat map showing RNA-seq expression data from TCGA for all the genes in identified clusters along with fold change comparisons (left) with normal vs. tumor and ERα − vs. ERα + samples. (B) A boxplot showing the significant difference in average gene expressions in each subset compared to normal for all the genes in MT1 gene cluster. (C) A boxplot showing significant difference in average MT1 cluster gene methylation for each subset compared to normal samples in our MDB-seq cohort.

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