DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia

Clinical Epigenetics

Table 2 Performance of classifiers designed using ALL samples with known subtype

Subtype group	Mean sensitivity ± SD	Mean specificity ± SD	Min CpGs ( N ) ^a	Max CpGs ( N ) ^a	Consensus CpGs ( N ) ^b
Reference	1.00 ± 0.01	0.99 ± 0.01	13	21	17
T-ALL	0.99 ± 0.02	1.00 ± 0.00	7	17	14
HeH	0.94 ± 0.04	0.95 ± 0.02	23	55	34
t(12;21)	0.97 ± 0.04	0.99 ± 0.01	28	2 263	42
11q23/MLL	0.95 ± 0.11	1.00 ± 0.00	16	27	28
t(1;19)	0.91 ± 0.13	1.00 ± 0.00	9	30	21
dic(9;20)	0.78 ± 0.16	0.99 ± 0.01	24	35	37
t(9;22)	0.70 ± 0.25	0.99 ± 0.01	17	41	23
iAMP21	0.81 ± 0.35	1.00 ± 0.00	11	19	16
Sex	0.98 ± 0.01	1.00 ± 0.01	8	12	14

^aThe minimum and maximum number of CpG sites chosen by each subtype classifier during cross validation.
^bThe number of CpG sites chosen for each subtype in the consensus classifier.

ISSN: 1868-7083