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Table 2 Performance of classifiers designed using ALL samples with known subtype

From: DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia

Subtype group Mean sensitivity ± SD Mean specificity ± SD Min CpGs ( N ) a Max CpGs ( N ) a Consensus CpGs ( N ) b
Reference 1.00 ± 0.01 0.99 ± 0.01 13 21 17
T-ALL 0.99 ± 0.02 1.00 ± 0.00 7 17 14
HeH 0.94 ± 0.04 0.95 ± 0.02 23 55 34
t(12;21) 0.97 ± 0.04 0.99 ± 0.01 28 2 263 42
11q23/MLL 0.95 ± 0.11 1.00 ± 0.00 16 27 28
t(1;19) 0.91 ± 0.13 1.00 ± 0.00 9 30 21
dic(9;20) 0.78 ± 0.16 0.99 ± 0.01 24 35 37
t(9;22) 0.70 ± 0.25 0.99 ± 0.01 17 41 23
iAMP21 0.81 ± 0.35 1.00 ± 0.00 11 19 16
Sex 0.98 ± 0.01 1.00 ± 0.01 8 12 14
  1. aThe minimum and maximum number of CpG sites chosen by each subtype classifier during cross validation.
  2. bThe number of CpG sites chosen for each subtype in the consensus classifier.