Figure 1

Schematic diagram of the location of CpG sites targeted in the promoter region of the IFNγ gene. CpG -54 corresponds to the murine counterpart CpG -53. Methylation levels at CpGs -54 and -186 have been shown to be mediated by environmental exposures and in association with allergic outcomes in animal models[14, 15] and asthma in human studies[5, 31]. CpG -295 is not conserved between mice and humans.