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Figure 1 | Clinical Epigenetics

Figure 1

From: DNA methylation of the allergy regulatory gene interferon gamma varies by age, sex, and tissue type in asthmatics

Figure 1

Schematic diagram of the location of CpG sites targeted in the promoter region of the IFNγ gene. CpG -54 corresponds to the murine counterpart CpG -53. Methylation levels at CpGs -54 and -186 have been shown to be mediated by environmental exposures and in association with allergic outcomes in animal models[14, 15] and asthma in human studies[5, 31]. CpG -295 is not conserved between mice and humans.

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