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Table 8 The effects of changes in DNA methylation on asthma transition between ages 10 and 18

From: The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition

Gene CpG sites Effects on transition; Log-OR (P value)
   (−,+)# (+,–)$
Dynamic methylation
GATA3 cg13543854 1.69 (0.22) −0.58 (0.78)
IL4R cg26937798 −3.11 (0.069) 3.97 (0.074)
IL4 cg23943829 3.56 (0.11) −0.99 (0.73)
Stable methylation
GATA3 cg12405139 −1.60 (0.64) 1.06 (0.71)
IL4R cg09791102 −21.18 (1.00) −0.67 (0.47)
  1. #(−,+): positive transition of asthma between ages 10 and 18 years.
  2. $(+,–): negative transition of asthma between ages 10 and 18 years.