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Table 6 The effects of SNP, DNA methylation, and their interactions in selected models ( IL4R )

From: The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition

Model Model frequency# Parameter   Effects at age 10 (n = 34); Log-OR (P value) Effects at age 18 (n = 233); Log-OR (P value$)
1 570 cg09791102   8.29 (0.53) −0.70 (0.2)
rs1110470 AA 42.92 (0.33) −3.93 (0.6)
GG 55.34 (0.24) −25.00 (0.004)
AG Ref. Ref.
cg09791102* rs1110470 AA −13.96 (0.34) 1.42 (0.6)
GG −18.83 (0.23) 8.51 (0.003)
AG Ref. Ref.
2 546 cg09791102   −6.52 (0.18) 3.27 (0.007)
rs1805011 AC −36.87 (1.00) 16.62 (0.02)
CC 22.14 (1.00) −5.22 (1.00)
AA Ref. Ref.
cg09791102* rs1805011 AC 6.51 (1.00) −5.88 (0.02)
CC NA −3.27 (1.00)
AA Ref. Ref.
3 571 cg09791102   −6.52 (0.18) 3.34 (0.006)
rs1805012 AG −36.87 (1.00) 17.16 (0.02)
GG 22.14 (1.00) −5.01 (1.00)
AA Ref. Ref.
cg09791102* rs1805012 AG 6.52 (1.00) −6.03 (0.02)
GG NA −3.34 (1.00)
AA Ref. Ref.
4 633 cg26937798   −4.91 (0.23) 1.53 (0.3)
rs3024685 AG 22.65 (0.11) −24.15 (0.002)
GG −4.59 (1.00) 0.62 (0.9)
AA Ref. Ref.
cg26937798* rs3024685 AG 8.63 (0.11) −8.37 (0.003)
GG 4.91 (1.00) 0.09 (0.9)
AA Ref. Ref.
5 761 cg26937798   0.01 (1.00) 0.09 (0.9)
rs8832 AA −16.93 (1.00) 10.38 (0.07)
GG −29.34 (0.59) −20.81 (0.01)
AG Ref. Ref.
cg26937798* rs8832 AA −0.01 (1.00) 3.73 (0.09)
GG −11.56 (0.59) −7.23 (0.01)
AG   Ref.
  1. #The frequency is based on 1,000 bootstrap samples.
  2. $P values significant at the 0.01 level at age 18 are in bold font.