Skip to main content

Table 6 The effects of SNP, DNA methylation, and their interactions in selected models ( IL4R )

From: The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition

Model

Model frequency#

Parameter

 

Effects at age 10 (n = 34); Log-OR (P value)

Effects at age 18 (n = 233); Log-OR (P value$)

1

570

cg09791102

 

8.29 (0.53)

−0.70 (0.2)

rs1110470

AA

42.92 (0.33)

−3.93 (0.6)

GG

55.34 (0.24)

−25.00 (0.004)

AG

Ref.

Ref.

cg09791102* rs1110470

AA

−13.96 (0.34)

1.42 (0.6)

GG

−18.83 (0.23)

8.51 (0.003)

AG

Ref.

Ref.

2

546

cg09791102

 

−6.52 (0.18)

3.27 (0.007)

rs1805011

AC

−36.87 (1.00)

16.62 (0.02)

CC

22.14 (1.00)

−5.22 (1.00)

AA

Ref.

Ref.

cg09791102* rs1805011

AC

6.51 (1.00)

−5.88 (0.02)

CC

NA

−3.27 (1.00)

AA

Ref.

Ref.

3

571

cg09791102

 

−6.52 (0.18)

3.34 (0.006)

rs1805012

AG

−36.87 (1.00)

17.16 (0.02)

GG

22.14 (1.00)

−5.01 (1.00)

AA

Ref.

Ref.

cg09791102* rs1805012

AG

6.52 (1.00)

−6.03 (0.02)

GG

NA

−3.34 (1.00)

AA

Ref.

Ref.

4

633

cg26937798

 

−4.91 (0.23)

1.53 (0.3)

rs3024685

AG

22.65 (0.11)

−24.15 (0.002)

GG

−4.59 (1.00)

0.62 (0.9)

AA

Ref.

Ref.

cg26937798* rs3024685

AG

8.63 (0.11)

−8.37 (0.003)

GG

4.91 (1.00)

0.09 (0.9)

AA

Ref.

Ref.

5

761

cg26937798

 

0.01 (1.00)

0.09 (0.9)

rs8832

AA

−16.93 (1.00)

10.38 (0.07)

GG

−29.34 (0.59)

−20.81 (0.01)

AG

Ref.

Ref.

cg26937798* rs8832

AA

−0.01 (1.00)

3.73 (0.09)

GG

−11.56 (0.59)

−7.23 (0.01)

AG

 

Ref.

  1. #The frequency is based on 1,000 bootstrap samples.
  2. $P values significant at the 0.01 level at age 18 are in bold font.