|
Gene
|
CpG sites
|
MapInfo§
|
Location
|
Chrom.
|
Mean at age 10 (SD)#
|
Mean at age 18 (SD)#
|
P value$
|
|---|
|
GATA3
|
cg12405139
|
8106035
|
Body
|
10
|
0.93 (0.0008)
|
0.92 (0.011)
|
0.12
|
|
GATA3
|
cg13543854
|
8095477
|
TSS200; TSS1500
|
10
|
0.047 (0.007)
|
0.042 (0.008)
|
5.84 × 10−3
|
|
IL4R
|
cg09791102
|
27353414
|
Body
|
16
|
0.94 (0.046)
|
0.94 (0.050)
|
0.14
|
|
IL4R
|
cg26937798
|
27326054
|
5’UTR
|
16
|
0.076 (0.022)
|
0.062 (0.013)
|
9.14 × 10−6
|
|
IL4
|
cg23943829
|
13200911
|
TSS1500
|
5
|
0.88 (0.016)
|
0.86 (0.019)
|
1.07 × 10−5
|
- §MapInfo refers to “genomic coordinates on the human genome” and it gives genomic location.
- #Means and standard deviations (SD) are calculated using beta values. Beta values are used to measure DNA methylation levels of each CpG site.
- $P values are from paired t-tests comparing the difference in DNA methylation between ages 10 and 18 years on logit-transformed beta values (to approximate normality).
- Mean and SD of DNA methylation of each CpG site are calculated in beta scores.
