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Table 2 Information on the CpG sites in the selected models before bootstrapping

From: The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition

Gene

CpG sites

MapInfo§

Location

Chrom.

Mean at age 10 (SD)#

Mean at age 18 (SD)#

P value$

GATA3

cg12405139

8106035

Body

10

0.93 (0.0008)

0.92 (0.011)

0.12

GATA3

cg13543854

8095477

TSS200; TSS1500

10

0.047 (0.007)

0.042 (0.008)

5.84 × 10−3

IL4R

cg09791102

27353414

Body

16

0.94 (0.046)

0.94 (0.050)

0.14

IL4R

cg26937798

27326054

5’UTR

16

0.076 (0.022)

0.062 (0.013)

9.14 × 10−6

IL4

cg23943829

13200911

TSS1500

5

0.88 (0.016)

0.86 (0.019)

1.07 × 10−5

  1. §MapInfo refers to “genomic coordinates on the human genome” and it gives genomic location.
  2. #Means and standard deviations (SD) are calculated using beta values. Beta values are used to measure DNA methylation levels of each CpG site.
  3. $P values are from paired t-tests comparing the difference in DNA methylation between ages 10 and 18 years on logit-transformed beta values (to approximate normality).
  4. Mean and SD of DNA methylation of each CpG site are calculated in beta scores.