Allelic variation in the canine Cox-2 promoter causes hypermethylation of the canine Cox-2 promoter in clinical cases of renal dysplasia

Table 1 Genotypes and clinical information for dogs used in this study

Case number	Breed	Biopsy	Genotype	Methylated DNA products	Source of DNA	Age at death from renal failure
1	Cocker spaniel	+	Allele1/Allele1	Allele1	Formalin preserved kidney tissue	2.5 years
2	Shih Tzu	+	Allele1/wt	Allele1	Cheek cells	4 months
3	Standard poodle	+	Allele2/wt	Allele2	Kidney	9 months
4	Lhasa apso	+	Allele2/Allele3	Allele2/Allele3	Kidney	8 years
5	Gordon Setter	+	Allele4/wt	Allele4	Cheek cells	3.5 years
6	Lhasa apso	-	wt/wt	None	Cheek cells	n/a
7	Miniature Schnauzer	-	Allele1/Allele1	None	Kidney	n/a
8	Lhasa apso	-	Allele2/Allele2	None	Cheek cells	n/a
9	English cocker spaniel	n/a	wt/wt	None	Cheek cells	n/a
10	Boxer	n/a	wt/wt	None	Cheek cells	n/a
11	Collie	n/a	wt/wt	None	Cheek cells	n/a
12	Collie	n/a	wt/wt	None	Cheek cells	n/a
13	Cocker spaniel	n/a	wt/wt	None	Cheek cells	n/a

ISSN: 1868-7083