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Figure 3 | Clinical Epigenetics

Figure 3

From: Allelic variation in the canine Cox-2 promoter causes hypermethylation of the canine Cox-2 promoter in clinical cases of renal dysplasia

Figure 3

Representative electropherograms from the DNA sequencing of bisulfite- converted DNA. (A) DNA that has not been converted with bisulfite (normal sequence). The primer set for this experiment was primer set 1 from reference [11]. (B) Wild-type allele showing that the CpG island of the Cox-2 promoter is unmethylated. (C) Electropherogram showing dense methylation of multiple alleles throughout the CpG island of the cyclooxygenase-2 (Cox-2) gene. (D) Electropherogram from Case number 2 (Shiz tzu) showing complete hypermethylation of the Cox-2 CpG island.

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Clinical Epigenetics

ISSN: 1868-7083

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