Skip to main content

Table 3 Sentinel CpG site summary and test statistics comparing never with current smokers, stratified by ethnicity

From: Differences in smoking associated DNA methylation patterns in South Asians and Europeans

Target ID

Chr

Location (bp)a

Gene ID or region

Median β-values (IQR) European

Effect size (%)b

F-statisticc

P-valuec

Median β-values (IQR) South Asian

Effect size (%)b

F-statisticc

P-valuec

Never smokers

Current smokers

Never smokers

Current smokers

cg09069072

1

15482753

TMEM51

0.86 (0.82, 0.88)

0.80 (0.76, 0.83)

-0.06

13.44

4.5 × 10-4

0.84 (0.82, 0.87)

0.79 (0.74, 0.83)

-0.05

17.82

6.2 × 10-5

cg25189904

1

68299493

GNG12

0.23 (0.19, 0.29)

0.16 (0.14, 0.17)

-0.07

28.75

8.0 × 10-7

0.28 (0.21, 0.34)

0.21 (0.18, 0.24)

-0.06

11.27

1.2 × 10-3

cg09935388

1

92947588

GFI1

0.54 (0.39, 0.76)

0.21 (0.20, 0.27)

-0.33

32.92

1.7 × 10-7

0.58 (0.43, 0.74)

0.34 (0.26, 0.45)

-0.24

17.07

8.6 × 10-5

cg21566642

2

233284661

2q37.1

0.49 (0.46, 0.53)

0.31 (0.28, 0.33)

-0.18

140.33

3.4 × 10-19

0.46 (0.39, 0.50)

0.35 (0.28, 0.37)

-0.12

57.96

4.1 × 10-11

cg03274391

3

22413232

3p24.3

0.30 (0.21, 0.45)

0.66 (0.53, 0.77)

0.36

40.10

1.4 × 10-8

0.33 (0.22, 0.44)

0.36 (0.27, 0.70)

0.03

6.05

1.6 × 10-2

cg05575921

5

373378

AHRR

0.77 (0.74, 0.79)

0.53 (0.50, 0.55)

-0.24

413.13

4.1 × 10-33

0.77 (0.74, 0.79)

0.57 (0.53, 0.62)

-0.19

295.15

6.7 × 10-29

cg13039251

5

32018601

PDZD2

0.72 (0.65, 0.80)

0.84 (0.77, 0.90)

0.12

16.88

9.7 × 10-5

0.71 (0.66, 0.79)

0.79 (0.74, 0.88)

0.08

17.00

8.9 × 10-5

cg06126421

6

30720080

6p21.33

0.72 (0.59, 0.78)

0.42 (0.38, 0.48)

-0.30

48.71

8.2 × 10-10

0.78 (0.68, 0.87)

0.65 (0.53, 0.71)

-0.14

21.23

1.5 × 10-5

cg17619755

6

31760629

VARS

0.61 (0.56, 0.65)

0.71 (0.63, 0.72)

0.10

22.31

9.9 × 10-6

0.62 (0.58, 0.67)

0.66 (0.64, 0.72)

0.04

11.07

1.3 × 10-3

cg22132788

7

45002486

MYO1G

0.81 (0.76, 0.88)

0.96 (0.94, 0.97)

0.15

84.27

4.3 × 10-14

0.84 (0.77, 0.90)

0.91 (0.87, 0.96)

0.07

24.83

3.4 × 10-6

cg01731783

14

74211788

C14orf43

0.41 (0.35, 0.44)

0.33 (0.31, 0.37)

-0.08

97.05

2.1 × 10-15

0.40 (0.35, 0.42)

0.32 (0.30, 0.38)

-0.08

16.28

1.2 × 10-4

cg03636183

19

17000585

F2RL3

0.36 (0.31, 0.39)

0.22 (0.19, 0.23)

-0.14

15.30

1.9 × 10-4

0.35 (0.32, 0.42)

0.27 (0.24, 0.30)

-0.08

24.68

3.6 × 10-6

  1. aLocation based on build37/hg19 reference assembly. bEffect size is calculated as the median methylation difference between smokers and non-smokers. Direction of difference is indicated by +/-. cF-statistic and P-values from ANOVA measuring association between smoking status and methylation in the ethnic sub-group.