Skip to main content

Table 3 Sentinel CpG site summary and test statistics comparing never with current smokers, stratified by ethnicity

From: Differences in smoking associated DNA methylation patterns in South Asians and Europeans

Target ID Chr Location (bp)a Gene ID or region Median β-values (IQR) European Effect size (%)b F-statisticc P-valuec Median β-values (IQR) South Asian Effect size (%)b F-statisticc P-valuec
Never smokers Current smokers Never smokers Current smokers
cg09069072 1 15482753 TMEM51 0.86 (0.82, 0.88) 0.80 (0.76, 0.83) -0.06 13.44 4.5 × 10-4 0.84 (0.82, 0.87) 0.79 (0.74, 0.83) -0.05 17.82 6.2 × 10-5
cg25189904 1 68299493 GNG12 0.23 (0.19, 0.29) 0.16 (0.14, 0.17) -0.07 28.75 8.0 × 10-7 0.28 (0.21, 0.34) 0.21 (0.18, 0.24) -0.06 11.27 1.2 × 10-3
cg09935388 1 92947588 GFI1 0.54 (0.39, 0.76) 0.21 (0.20, 0.27) -0.33 32.92 1.7 × 10-7 0.58 (0.43, 0.74) 0.34 (0.26, 0.45) -0.24 17.07 8.6 × 10-5
cg21566642 2 233284661 2q37.1 0.49 (0.46, 0.53) 0.31 (0.28, 0.33) -0.18 140.33 3.4 × 10-19 0.46 (0.39, 0.50) 0.35 (0.28, 0.37) -0.12 57.96 4.1 × 10-11
cg03274391 3 22413232 3p24.3 0.30 (0.21, 0.45) 0.66 (0.53, 0.77) 0.36 40.10 1.4 × 10-8 0.33 (0.22, 0.44) 0.36 (0.27, 0.70) 0.03 6.05 1.6 × 10-2
cg05575921 5 373378 AHRR 0.77 (0.74, 0.79) 0.53 (0.50, 0.55) -0.24 413.13 4.1 × 10-33 0.77 (0.74, 0.79) 0.57 (0.53, 0.62) -0.19 295.15 6.7 × 10-29
cg13039251 5 32018601 PDZD2 0.72 (0.65, 0.80) 0.84 (0.77, 0.90) 0.12 16.88 9.7 × 10-5 0.71 (0.66, 0.79) 0.79 (0.74, 0.88) 0.08 17.00 8.9 × 10-5
cg06126421 6 30720080 6p21.33 0.72 (0.59, 0.78) 0.42 (0.38, 0.48) -0.30 48.71 8.2 × 10-10 0.78 (0.68, 0.87) 0.65 (0.53, 0.71) -0.14 21.23 1.5 × 10-5
cg17619755 6 31760629 VARS 0.61 (0.56, 0.65) 0.71 (0.63, 0.72) 0.10 22.31 9.9 × 10-6 0.62 (0.58, 0.67) 0.66 (0.64, 0.72) 0.04 11.07 1.3 × 10-3
cg22132788 7 45002486 MYO1G 0.81 (0.76, 0.88) 0.96 (0.94, 0.97) 0.15 84.27 4.3 × 10-14 0.84 (0.77, 0.90) 0.91 (0.87, 0.96) 0.07 24.83 3.4 × 10-6
cg01731783 14 74211788 C14orf43 0.41 (0.35, 0.44) 0.33 (0.31, 0.37) -0.08 97.05 2.1 × 10-15 0.40 (0.35, 0.42) 0.32 (0.30, 0.38) -0.08 16.28 1.2 × 10-4
cg03636183 19 17000585 F2RL3 0.36 (0.31, 0.39) 0.22 (0.19, 0.23) -0.14 15.30 1.9 × 10-4 0.35 (0.32, 0.42) 0.27 (0.24, 0.30) -0.08 24.68 3.6 × 10-6
  1. aLocation based on build37/hg19 reference assembly. bEffect size is calculated as the median methylation difference between smokers and non-smokers. Direction of difference is indicated by +/-. cF-statistic and P-values from ANOVA measuring association between smoking status and methylation in the ethnic sub-group.