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Table 2 Summary and test statistics for the 12 sentinel CpG sites comparing never with current smokers

From: Differences in smoking associated DNA methylation patterns in South Asians and Europeans

Target ID Chr Location (bp)a Gene ID or region Relation to CpG island Median β-values (IQR) all samples Effect size (%)b F-statisticc P-valuec Rank
Never smokers Current smokers
cg09069072 1 15482753 TMEM51 South Shore 0.85 (0.82, 0.87) 0.79 (0.75, 0.83) -0.06 31.49 8.5 × 10-8 11
cg25189904 1 68299493 GNG12 South Shore 0.25 (0.20, 0.32) 0.18 (0.16, 0.22) -0.07 35.05 1.9 × 10-8 7
cg09935388 1 92947588 GFI1 CpG Island 0.57 (0.42, 0.75) 0.27 (0.21, 0.38) -0.30 47.85 1.0 × 10-10 6
cg21566642 2 233284661 2q37.1 CpG Island 0.49 (0.43, 0.52) 0.32 (0.28, 0.37) -0.16 172.13 3.0 × 10-27 2
cg03274391 3 22413232 3p24.3 North Shore 0.31 (0.21, 0.44) 0.56 (0.34, 0.75) +0.25 34.56 2.3 × 10-8 8
cg05575921 5 373378 AHRR North Shore 0.77 (0.74, 0.79) 0.55 (0.52, 0.58) -0.22 658.31 6.1 × 10-59 1
cg13039251 5 32018601 PDZD2   0.71 (0.65, 0.79) 0.83 (0.76, 0.89) +0.11 33.46 3.7 × 10-8 9
cg06126421 6 30720080 6p21.33   0.75 (0.64, 0.82) 0.52 (0.41, 0.66) -0.23 63.64 2.6 × 10-13 5
cg17619755 6 31760629 VARS North Shelf 0.61 (0.57, 0.65) 0.67 (0.63, 0.72) +0.05 31.89 7.2 × 10-8 10
cg22132788 7 45002486 MYO1G CpG Island 0.83 (0.76, 0.89) 0.95 (0.90, 0.97) +0.12 89.85 3.1 × 10-17 4
cg01731783 14 74211788 C14orf43   0.40 (0.35, 0.43) 0.33 (0.31, 0.37) -0.07 31.46 8.6 × 10-8 12
cg03636183 19 17000585 F2RL3 North Shore 0.36 (0.31, 0.40) 0.23 (0.20, 0.28) -0.12 93.30 1.0 × 10-17 3
  1. alocation based on build37/hg19 reference assembly. bEffect size is calculated as the median methylation difference between smokers and non-smokers. Direction of difference is indicated by +/-. cF-statistic and P-values from ANOVA measuring association between smoking status and methylation adjusted for ethnic group.