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Table 1 Baseline characteristics of individuals and aberrant crypt foci in each colon cancer risk group

From: LINE-1 hypomethylation is neither present in rectal aberrant crypt foci nor associated with field defect in sporadic colorectal neoplasia

 

Control (n = 70)

Adenoma (n = 42)

Colon cancer (n = 35)

Sex, n (%)

   

  – Female

48 (68.6%)

17 (40.5%)

13 (37.1%)

  – Male

22 (31.4%)

25 (59.5%)

22 (62.9%)

Age, years, mean ± SD

58.1 ± 15.3

68.6 ± 9.9

66.8 ± 8.6

Colon cancer location, n (%)

   

  – Sigmoid

–

–

21 (60%)

  – Descending

–

–

2 (5.7%)

  – Transverse

–

–

1 (2.9%)

  – Ascending

–

–

9 (25.7%)

  – Cecum

–

–

2 (5.7%)

Colon cancer TNM stage, n (%)

   

  – I

–

–

10 (28.6%)

  – II

–

–

11 (31.4%)

  – III

–

–

13 (37.1%)

  – IV

–

–

1 (2.9%)

Adenoma features (per patient)a

   

  – Tubular, n (%)

–

28 (70%)

11 (31.4%)

  – Tubulovillous, n (%)

–

7 (17.5%)

1 (2.9%)

  – Villous, n (%)

–

5 (12.5%)

0 (0%)

  – High-grade dysplasia, n (%)

–

11 (27.5%)

5 (14.3%)

  – Adenoma size, mean (mm) ± SD

–

12.3 ± 9.8

8.4 ± 5

  – Number of adenomas per patient, mean ± SD (range)

–

2.4 ± 2 (1 to 9)

1.2 ± 1.2 (1 to 4)

Advanced adenomab, n (%)

 

22 (55%)

7 (20%)

Adenoma location (per patient)c, n (%)

   

  – Rectum

–

12 (30%)

2 (5.7%)

  – Sigmoid

–

10 (25%)

3 (8.6%)

  – Descending

–

5 (12.5%)

3 (8.6%)

  – Transverse

–

5 (12.5%)

2 (5.7%)

  – Ascending

–

5 (12.5%)

2 (5.7%)

  – Cecum

–

3 (7.5%)

0 (0%)

Serrated polyps features (per patient)d

   

  – Recto-sigmoid hyperplastic polyps, n (%)

–

12 (30%)

3 (8.6%)

  – Proximal serrated polyps, n (%)e

–

4 (10%)

5 (14.3%)

  – Serrated polyps ≥10 mm, n (%)

–

2 (5%)

2 (5.7%)

  – Serrated polyps per patient, n, mean ± SD (range)

–

1.6 ± 0.8 (1 to 3)

3.1 ± 3.4 (1 to 5)

  – Hyperplastic polyp, n (%)

–

15 (37.5%)

8 (22.9%)

  – Sessile serrated adenoma, n (%)

–

1 (%)

0 (0%)

  –Traditional serrated adenoma, n (%)

–

0 (%)

0 (0%)

ACF for molecular study, n

117

76

77

Dysplastic ACF, n (%)

24 (17.4%)

23 (24%)

17 (25%)

Hyperplastic ACF, n (%)

114 (82.6%)

73 (76%)

51 (75%)

  1. ACF, aberrant crypt foci; SD, standard deviation.
  2. aThis referred to 40 individuals in the adenoma group for whom full pathological information about the adenomas was available.
  3. bAdvanced adenoma: ≥10 mm in size, or presence of high-grade dysplasia or villous features.
  4. cIn cases with >1 adenoma, this referred to the location of the most advanced adenoma.
  5. dIncluded hyperplastic polyps, sessile serrated adenomas, and traditional serrated adenomas.
  6. eProximal to the sigmoid colon.
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Clinical Epigenetics

ISSN: 1868-7083

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