Figure 2

Immunohistochemistry (IHC) scores for RhoA were significantly higher in post-decitabine tumor biopsies compared to pre-decitabine biopsies. (a, n = 19, median scores 77.5 post-decitabine versus 50 pre-decitabine, with an increase in scores in 14 of 18 patients, P = 0.03). There was a trend towards higher scores in post-decitabine samples compared to pre-decitabine samples for RFC1. (b, n = 21, median scores 90 versus 90, with an increase in 14 of 21, P = 0.17). In patients with pre-decitabine scores ≤150, there was a significant increase in RFC1 scores with decitabine (c, n = 17, median scores 95 post-decitabine versus 80 pre-decitabine, with an increase in RFC1 scores in 13 of 17 patients, P = 0.004). There was no increase with decitabine in scores for FOLR1 (d, n = 19, median scores 80 in both pre- and post-decitabine samples, P = 0.89) or for GLUT4 (e, n = 20, median scores 10 post-decitabine versus 5 pre-decitabine, P = 0.61).