High-frequency aberrantly methylated targets in pancreatic adenocarcinoma identified via global DNA methylation analysis using methylCap-seq

Table 3 Aberrantly hypermethylated miRNAs in PC and PN in present and previous studies

	Names	Differently methylated region location in genome	-10log ( P)*	Transcription direction	References
Hypermethylated	hsa-mir-9-3	chr15:89908727-89909052	78.11	Sense	[24]
	hsa-mir-9-1	chr1:156389946-156390692	81.02	Antisense	[25]
	hsa-mir-124-3	chr20:61806943-61807560	30.36	Sense	[21]
	hsa-mir-10b	chr2:177013457-177013940	366.4	Sense	[28, 29]
	hsa-mir-124-2	chr8:65289087-65292713	387.77	Sense	[20, 26]
	hsa-mir-718	chrX:153284470-153285204	65.44	Antisense
	hsa-mir-203	chr14:104584097-104584701	92.85	Sense	[27]
Hypomethylated	hsa-mir-210	chr11:569133-569765	95.42	Antisense	[23]
	hsa-mir-1469	chr15:96877281-96877871	81.68	Sense
	hsa-mir-130b	chr22:22006547-22007358	143.05	Sense	[22]
	hsa-mir-149	chr2:241395079-241395714	58.15	Sense
	hsa-mir-1224	chr3:183958940-183960006	126.15	Sense
	hsa-mir-564	chr3:44902453-44903064	46.02	Sense

*Logarithmic transformation of P to show significance level of the differential methylation region (in differently methylated region (DMR) estimation) or methylation blocks (model-based analysis of ChIP-Seq). The higher this value, the higher the probability inferred for DMR or methylation block.

ISSN: 1868-7083