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Table 2 Gene ontology enrichment analysis of aberrant methylation in gene promoters in PC and PN

From: High-frequency aberrantly methylated targets in pancreatic adenocarcinoma identified via global DNA methylation analysis using methylCap-seq

 

Category

Term

Genes in list

Total genes

-log10 ( P)*

Hypermethylated promoter related gene (615)

GOTERM_MF_FAT

GO:0043565 sequence-specific DNA binding

61

607

8.47 × 10-16

GOTERM_BP_FAT

GO:0030182 neuron differentiation

47

438

5.06 × 10-13

GOTERM_BP_FAT

GO:0006355 regulation of transcription, DNA-dependent

111

1773

5.08 × 10-13

GOTERM_BP_FAT

GO:0000904 cell morphogenesis involved in differentiation

29

244

3.07 × 10-9

GOTERM_BP_FAT

GO:0006928 cell motion

41

475

1.30 × 10-8

GOTERM_BP_FAT

GO:0007267 cell-cell signaling

47

600

1.88 × 10-8

GOTERM_CC_FAT

GO:0043005 neuron projection

31

342

4.13 × 10-8

GOTERM_CC_FAT

GO:0045202 synapse

28

355

3.28 × 10-6

GOTERM_CC_FAT

GO:0044459 plasma membrane part

96

2203

9.52 × 10-6

GOTERM_CC_FAT

GO:0005887 integral to plasma membrane

60

1188

1.40 × 10-5

GOTERM_CC_FAT

GO:0044456 synapse part

21

246

2.43 × 10-5

GOTERM_MF_FAT

GO:0022836 gated channel activity

24

310

1.03 × 10-4

GOTERM_MF_FAT

GO:0005021 vascular endothelial growth factor receptor activity

4

8

1.48 × 10-3

GOTERM_MF_FAT

GO:0003702 RNA polymerase II transcription factor activity

18

244

1.61 × 10-3

GOTERM_MF_FAT

GO:0030955 potassium ion binding

12

128

2.12 × 10-3

KEGG_PATHWAY

hsa04080 neuroactive ligand-receptor interaction

17

256

3.33 × 10-3

Hypomethylated promoter related gene (383)

GOTERM_CC_FAT

GO:0044459 plasma membrane part

63

2203

2.05 × 10-5

GOTERM_MF_FAT

GO:0016247 channel regulator activity

6

59

3.00 × 10-3

GOTERM_BP_FAT

GO:0030513 positive regulation of BMP signaling pathway

3

6

4.06 × 10-3

GOTERM_BP_FAT

GO:0051260 protein homooligomerization

7

95

5.36 × 10-3

GOTERM_BP_FAT

GO:0030182 neuron differentiation

16

438

7.41 × 10-3

GOTERM_BP_FAT

GO:0048732 gland development

8

135

7.90 × 10-3

GOTERM_BP_FAT

GO:0031328 positive regulation of cellular biosynthetic process

21

685

1.19 × 10-2

GOTERM_CC_FAT

GO:0005902 microvillus

4

36

2.28 × 10-2

GOTERM_CC_FAT

GO:0032420 stereocilium

3

15

2.60 × 10-2

GOTERM_CC_FAT

GO:0032421 stereocilium bundle

3

17

3.30 × 10-2

GOTERM_MF_FAT

GO:0016524 latrotoxin receptor activity

2

2

3.32 × 10-2

GOTERM_CC_FAT

GO:0005923 tight junction

5

73

3.54 × 10-2

GOTERM_MF_FAT

GO:0003700 transcription factor activity

25

975

3.60 × 10-2

GOTERM_MF_FAT

GO:0005261 cation channel activity

10

275

4.12 × 10-2

  1. *Logarithmic transformation of P to show significance level of the differential methylation region (in differently methylated region (DMR) estimation) or methylation blocks (model-based analysis of ChIP-Seq). The higher this value, the higher the probability inferred for DMR or methylation blocks.
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Clinical Epigenetics

ISSN: 1868-7083

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