Table 4 Assessment of interaction of single nucleotide polymorphisms with oral contraceptive use, and with age at menarche on the methylation of the CpG site cg17124583 using linear regression a
Parameter | Estimate (Standard error) | P value | |||
|---|---|---|---|---|---|
Not adjusted for cell type | Adjusted for cell type | Not adjusted for cell type | Adjusted for cell typea | ||
OCP use | 0.12 (0.11) | 0.16 (0.11) | 0.28 | 0.16 | |
rs1269486 | AA | 0.64 (0.24) | 0.68 (0.25) | 0.009 | 0.006 |
AG | 0.41 (0.12) | 042 (0.13) | 0.001 | 0.001 | |
GG | Reference | ||||
OCP use × rs1269486 | AA | -0.72 (0.39) | -0.86 (0.40) | 0.06 | 0.03 |
AG | -0.55 (0.18) | -0.57 (0.18) | 0.002 | 0.002 | |
GG | Reference | ||||
Age at menarche | -0.09 (0.04) | -0.09 (0.04) | 0.05 | 0.06 | |
rs1269486 | AA | -5.28 (1.77) | -4.87 (1.78) | 0.003 | 0.006 |
AG | -1.12 (0.86) | -1.06 (0.86) | 0.19 | 0.21 | |
GG | Reference | ||||
Age at menarche × rs1269486 | AA | 0.45 (0.14) | 0.42 (0.14) | 0.001 | 0.003 |
AG | 0.09 (0.06) | 0.09 (0.06) | 0.14 | 0.16 | |
GG | Reference | ||||