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Table 4 Assessment of interaction of single nucleotide polymorphisms with oral contraceptive use, and with age at menarche on the methylation of the CpG site cg17124583 using linear regression a

From: Oral contraceptives modify the effect of GATA3 polymorphisms on the risk of asthma at the age of 18 years via DNA methylation

Parameter Estimate (Standard error) P value
Not adjusted for cell type Adjusted for cell type Not adjusted for cell type Adjusted for cell typea
OCP use   0.12 (0.11) 0.16 (0.11) 0.28 0.16
rs1269486 AA 0.64 (0.24) 0.68 (0.25) 0.009 0.006
AG 0.41 (0.12) 042 (0.13) 0.001 0.001
GG Reference    
OCP use × rs1269486 AA -0.72 (0.39) -0.86 (0.40) 0.06 0.03
AG -0.55 (0.18) -0.57 (0.18) 0.002 0.002
GG Reference    
Age at menarche   -0.09 (0.04) -0.09 (0.04) 0.05 0.06
rs1269486 AA -5.28 (1.77) -4.87 (1.78) 0.003 0.006
AG -1.12 (0.86) -1.06 (0.86) 0.19 0.21
GG Reference    
Age at menarche × rs1269486 AA 0.45 (0.14) 0.42 (0.14) 0.001 0.003
AG 0.09 (0.06) 0.09 (0.06) 0.14 0.16
GG Reference    
  1. aAdjusted for socioeconomic status, smoking at 18 years, BMI at 18 years, and cell mixture of the peripheral blood using the Houseman formula [41].