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Figure 5 | Clinical Epigenetics

Figure 5

From: High-throughput DNA analysis shows the importance of methylation in the control of immune inflammatory gene transcription in chronic periodontitis

Figure 5

Pattern of methyl score sign in the promoter region (0 to āˆ’1,700) of all three groups. Genes with probes with only negative methyl scores (neg), only positive methyl scores (pos), and both positive and negative methyl scores (negpos). (A) Number of immune-inflammatory genes. (B) Number of cell cycle genes. (C) Number of stably expressed genes. Note that the frequency of genes with only negative methyl scores was higher in the immune group (30.9%) than in the cell cycle (8.9%) and stable (2.7%) groups, indicating a higher frequency of clustered demethylation of the genes related to the immune process during periodontitis (chi-squared test, pā€‰<ā€‰2.2eā€‰āˆ’ā€‰16).

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