Table 1 Characteristics of men according to their coronary artery disease status
Characteristics | Younger men without CAD (n = 25) | Older men without CAD (n = 25) | Younger men with CAD (n = 19) | Older men with CAD (n = 19) | P-value | Adjusted P-valuea |
|---|---|---|---|---|---|---|
Age (years) | 53.6 ± 1.4 | 72.6 ± 1.5 | 54.3 ± 1.9 | 73.4 ± 1.9 | <0.001 | - |
BMI (kg/m2) | 28.1 ± 1.1 | 27.0 ± 0.7 | 29.0 ± 1.2 | 26.3 ± 0.5 | 0.21 | 0.33 |
Waist circumference (cm) | 100.4 ± 3.2 | 99.9 ± 1.7 | 102.2 ± 3.3 | 100.6 ± 1.7 | 0.94 | 0.81 |
Glucose (mmol/L) | 5.12 ± 0.23 | 5.73 ± 0.20 | 6.00 ± 0.27 | 5.50 ± 0.20 | 0.06 | 0.06 |
Total cholesterol (mmol/L) | 4.61 ± 0.20 | 3.78 ± 0.21 | 4.33 ± 0.30 | 3.91 ± 0.19 | 0.03 | 0.48 |
LDL-C (mmol/L) | 2.58 ± 0.16 | 2.02 ± 0.17 | 2.67 ± 0.27 | 2.14 ± 0.16 | 0.04 | 0.63 |
HDL-C (mmol/L) | 1.22 ± 0.08 | 1.16 ± 0.06 | 1.03 ± 0.05 | 1.12 ± 0.06 | 0.21 | 0.20 |
Fasting triglyceridemia (mmol/L)b | 1.58 ± 0.37 | 1.22 ± 0.14 | 1.48 ± 0.12 | 1.33 ± 0.11 | 0.27 | 0.79 |
Smoking (ever/never) | 15/10 | 14/11 | 14/5 | 9/9 | 0.50 | - |
Medication (%) | ||||||
ARB | 4 (16) | 5 (20) | 5 (26.3) | 4 (21.1) | 0.89 | - |
ASA | 6 (24) | 9 (36) | 11 (57.9) | 16 (84.2) | <0.001 | - |
β-Blocker | 8 (32) | 7 (28) | 9 (47.4) | 11 (57.9) | 0.16 | - |
Diuretic | 8 (32) | 10 (40) | 3 (15.8) | 5 (26.3) | 0.36 | - |
Calcium channel blocker | 2 (8) | 6 (24) | 9 (47.4) | 7 (36.8) | 0.02 | - |
Lipid-lowering drugs | 8 (32) | 17 (68) | 12 (63.2) | 18 (94.7) | 0.003 | - |
ACE inhibitors | 11 (44) | 8 (32) | 8 (42.1) | 6 (31.6) | 0.75 | - |
Nitroglycerine | 1 (4) | 4 (16) | 5 (26.3) | 9 (47.4) | 0.005 | - |
Mean ABCA1 DNA methylation (%) | 36.1 ± 1.5 | 35.9 ± 1.5 | 33.9 ± 1.3 | 40.7 ± 2.0c,d,e | 0.04 | <0.001 |