Skip to main content

Table 1 Characteristics of men according to their coronary artery disease status

From: Acetylsalicylic acid, aging and coronary artery disease are associated with ABCA1 DNA methylation in men

Characteristics Younger men without CAD (n = 25) Older men without CAD (n = 25) Younger men with CAD (n = 19) Older men with CAD (n = 19) P-value Adjusted P-valuea
Age (years) 53.6 ± 1.4 72.6 ± 1.5 54.3 ± 1.9 73.4 ± 1.9 <0.001 -
BMI (kg/m2) 28.1 ± 1.1 27.0 ± 0.7 29.0 ± 1.2 26.3 ± 0.5 0.21 0.33
Waist circumference (cm) 100.4 ± 3.2 99.9 ± 1.7 102.2 ± 3.3 100.6 ± 1.7 0.94 0.81
Glucose (mmol/L) 5.12 ± 0.23 5.73 ± 0.20 6.00 ± 0.27 5.50 ± 0.20 0.06 0.06
Total cholesterol (mmol/L) 4.61 ± 0.20 3.78 ± 0.21 4.33 ± 0.30 3.91 ± 0.19 0.03 0.48
LDL-C (mmol/L) 2.58 ± 0.16 2.02 ± 0.17 2.67 ± 0.27 2.14 ± 0.16 0.04 0.63
HDL-C (mmol/L) 1.22 ± 0.08 1.16 ± 0.06 1.03 ± 0.05 1.12 ± 0.06 0.21 0.20
Fasting triglyceridemia (mmol/L)b 1.58 ± 0.37 1.22 ± 0.14 1.48 ± 0.12 1.33 ± 0.11 0.27 0.79
Smoking (ever/never) 15/10 14/11 14/5 9/9 0.50 -
Medication (%)       
  ARB 4 (16) 5 (20) 5 (26.3) 4 (21.1) 0.89 -
  ASA 6 (24) 9 (36) 11 (57.9) 16 (84.2) <0.001 -
  β-Blocker 8 (32) 7 (28) 9 (47.4) 11 (57.9) 0.16 -
  Diuretic 8 (32) 10 (40) 3 (15.8) 5 (26.3) 0.36 -
  Calcium channel blocker 2 (8) 6 (24) 9 (47.4) 7 (36.8) 0.02 -
  Lipid-lowering drugs 8 (32) 17 (68) 12 (63.2) 18 (94.7) 0.003 -
  ACE inhibitors 11 (44) 8 (32) 8 (42.1) 6 (31.6) 0.75 -
  Nitroglycerine 1 (4) 4 (16) 5 (26.3) 9 (47.4) 0.005 -
Mean ABCA1 DNA methylation (%) 36.1 ± 1.5 35.9 ± 1.5 33.9 ± 1.3 40.7 ± 2.0c,d,e 0.04 <0.001
  1. Results are shown as mean ± SEM unless otherwise stated. Statistically significant results are shown in bold. aP-values were obtained following an analysis of covariance including age and ASA as covariables. bGeometric mean and P-value obtained after log10-transformation of the variable. cP ≤ 0.05, compared to younger men without CAD following Bonferroni’s post-hoc comparison test; dP < 0.05 compared to older men without CAD following Bonferroni’s post-hoc comparison test; eP < 0.05 compared to younger men with CAD following Bonferroni’s post-hoc comparison test. ABCA1, ATP-binding cassette transporter A1; ACE, angiotensin-converting enzyme; ARB, aldosterone receptor blocker; ASA, acetylsalicylic acid; BMI, body mass index; CAD, coronary artery disease; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.