Figure 3From: Acetylsalicylic acid, aging and coronary artery disease are associated with ABCA1 DNA methylation in menAssociation between ABCA1 DNA methylation levels and acetylsalicylic acid therapy. Subjects on acetylsalicylic acid (ASA) therapy had lower mean ATP-binding cassette transporter A1 (ABCA1) DNA methylation levels (Δ = −3.6%) compared to subjects not on ASA therapy, independent of age and CAD. In subjects without CAD, we observed the same significant association between ASA and a lower mean ABCA1 DNA methylation level (Δ = −4.7%; P = 0.01). Although not significant, we observed that in subjects with CAD, those under an ASA treatment exhibited a similar decrease in mean ABCA1 DNA methylation levels (Δ = −3.9%; P = 0.14). aP-values were obtained after consideration of age. bP-value was obtained after consideration of age and CAD status.Back to article page