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Table 3 Genes positively associated with schizophrenia where methylation changed in response to olanzapine

From: The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum

Genea

Reference (PubMedID)

Affected in

Peak length (bp)

Peak to transcription start site (bp)

Promoter class

Nos1

20645313

Hippocampus

334

-3,719

LCP

Map6

16624526

Hippocampus

169

-2,382

ICP

Drd5

11304828

Hippocampus

844

41

HCP

Cacna1c

23183239

Hippocampus

425

-3,692

LCP

Bdnf

16818862

Hippocampus

329

-492

ICP

Gsksb

18500637

Hippocampus

573

-1,042

HCP

Tf

18045615

Hippocampus

159

-3,020

LCP

Cnp

16389193

Hippocampus

464

1,198

HCP

Amacr

20875727

Hippocampus

558

164

HCP

Psen2

19232479

Hippocampus

249

620

LCP

Pax6

10376119

Hippocampus

341

326

ICP

Dlx1

18384059

Hippocampus

431

-2,043

HCP

Dlx1

18384059

Cerebellum

1,330

257

HCP

Cnp

16389193

Cerebellum

769

940

HCP

Psen2

19232479

Cerebellum

455

442

LCP

Pax6

10376119

Cerebellum

349

-3,481

ICP

Stx1a

15219469

Cerebellum

149

72

HCP

Drd5

11304828

Cerebellum

264

-169

HCP

Mmp9

20037727

Cerebellum

138

-325

LCP

Tnf

11244489

Cerebellum

269

49

LCP

Grin1

12679240

Cerebellum

264

-1,595

HCP

Tf

18045615

Cerebellum

749

-1,704

LCP

Dlg4

21151988

Cerebellum

134

-1,459

LCP

Amacr

20875727

Cerebellum

138

-48

HCP

Dao

19685198

Cerebellum

287

-2,385

LCP

Dlx1

18384059

Liver

171

-2,993

HCP

Cnp

16389193

Liver

644

-2,644

HCP

Sod2

15193990

Liver

550

594

HCP

Drd5

11304828

Liver

369

-316

HCP

Il6

20393813

Liver

789

-3,030

LCP

Comt

11381111

Liver

638

-3,542

HCP

Apoe

14674716

Liver

2,158

-1,223

LCP

Drd2

18829695

Liver

257

-91

HCP

Nos1

20645313

Liver

348

172

LCP

Drd1

20127886

Liver

540

739

LCP

  1. aAll genes except Nos1, Map6, Il6 and Comt had increased methylation in olanzapine-treated rats.
  2. HCP, high CpG contents; ICP, intermediate CpG contents; LCP, low CpG contents.