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Table 2 Top networks identified by pathway analysis for the cerebellum following olanzapine treatment

From: The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum

(a) Top canonical pathways (Genes with increased methylation)

P- value

No of moleculesa

Ephrin receptor signalling

5.23 × 10–4

24/176 (0.136)

Erk/Mapk signalling

1.59 × 10–3

24/184 (0.130)

Circadian rhythm signalling

1.94 × 10–3

8/33 (0.242)

Protein kinase A signalling

2.61 × 10–3

41/372 (0.110)

Synaptic long-term potentiation

2.94 × 10–3

17/113 (0.150)

Associated network functions

 

Cardiovascular disease, cell signalling, small molecule biochemistry

25

Cellular development, tissue morphology, cardiac dilation

23

Molecular transport, protein synthesis, protein trafficking

12

Behaviour, nervous system development and function

11

Neurological disease, psychological disorders, cell-to-cell signalling

10

(b) Top canonical pathways (Genes with decreased methylation)

P- value

No of molecules

Ephrin B signalling

4.0 × 10–3

7/72 (0.097)

G beta gamma signalling

4.1 × 10–3

8/99 (0.081)

Germ cell-Sertoli cell junction signalling

5.0 × 10–3

11/148 (0.074)

tRNA splicing

8.3 × 10–3

4/32 (0.125)

Tetrahydrofolate salvage from 5, 10 methenyltetrahydrofolate

8.6 × 10–3

2/6 (0.333)

Associated network functions

  

Cell death and survival, cellular development

14

Energy production, lipid metabolism, small molecule biochemistry

14

DNA replication and repair, development, carbohydrate metabolism

14

Neurological disease, cellular function and maintenance, molecular transport

11

  1. aFor the top canonical pathways, the ratio is the number of molecules in a given pathway that meet the cut-off (P ≤ 0.01) divided by the total number of molecules in the pathway.