From: The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum
(a) Top canonical pathways (Genes with increased methylation) | P- value | No of moleculesa |
---|---|---|
Ephrin receptor signalling | 5.23 × 10–4 | 24/176 (0.136) |
Erk/Mapk signalling | 1.59 × 10–3 | 24/184 (0.130) |
Circadian rhythm signalling | 1.94 × 10–3 | 8/33 (0.242) |
Protein kinase A signalling | 2.61 × 10–3 | 41/372 (0.110) |
Synaptic long-term potentiation | 2.94 × 10–3 | 17/113 (0.150) |
Associated network functions | Â | |
Cardiovascular disease, cell signalling, small molecule biochemistry | 25 | |
Cellular development, tissue morphology, cardiac dilation | 23 | |
Molecular transport, protein synthesis, protein trafficking | 12 | |
Behaviour, nervous system development and function | 11 | |
Neurological disease, psychological disorders, cell-to-cell signalling | 10 | |
(b) Top canonical pathways (Genes with decreased methylation) | P- value | No of molecules |
Ephrin B signalling | 4.0 × 10–3 | 7/72 (0.097) |
G beta gamma signalling | 4.1 × 10–3 | 8/99 (0.081) |
Germ cell-Sertoli cell junction signalling | 5.0 × 10–3 | 11/148 (0.074) |
tRNA splicing | 8.3 × 10–3 | 4/32 (0.125) |
Tetrahydrofolate salvage from 5, 10 methenyltetrahydrofolate | 8.6 × 10–3 | 2/6 (0.333) |
Associated network functions | Â | Â |
Cell death and survival, cellular development | 14 | |
Energy production, lipid metabolism, small molecule biochemistry | 14 | |
DNA replication and repair, development, carbohydrate metabolism | 14 | |
Neurological disease, cellular function and maintenance, molecular transport | 11 |