DNMT1 genetic polymorphisms affect breast cancer risk in the central European Caucasian population

Clinical Epigenetics

Table 3 Genotype distribution as listed in the NCBI database compared to data obtained in this study

SNP	Number of samples (NCBI data)	Number of samples (study results)	Wildtype (NCBI data)	Wildtype (study results)	Heterozygote (NCBI data)	Heterozygote (study results)	Variant (NCBI data)	Variant (study results)
DNMT1 SNP	226	221^a	88.50%	87.3%^a	11.50%	12.7%^a	5.80%	0%^a
(A201G, rs2228612)		221^b		81.4%^b		15.8%^b		2.7%^b
DNMT3A SNP	74	221^a	97.30%	100%^a	2.70%	0%^a	1.40%	0%^a
(G301C, rs34843713)		221^b		100%^b		0%^b		0%^b
DNMT3A SNP	68	221^a	97.10%	100%^a	2.90%	0%^a	1.50%	0%^a
(G301A, rs34191084)		221^b		100%^b		0%^b		0%^b
DNMT3B SNP	120	221^a	75%	69.7%^a	25%	28%^a	12.50%	2.3%^a
(C501T, rs406193)		221^b		77.8%^b		20.8%^b		1.4%^b
DNMT3B SNP	74	221^a	97.30%	100%^a	2.70%	0%^a	1.40%	0%^a
(G301A, rs35846833)		221^b		100%^b		0%^b		0%^b

^aResults of cases; ^bresults of controls. NCBI, National Center for Biotechnology Information.

ISSN: 1868-7083