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Table 1 Silencing by DNA methylation of key genes in different types of cancer a

From: Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy

Genes

Type of cancer

p16, p14, RARβ2, SFRP1

Colon cancer

p16, p14

Esophageal cancer

p14, hMLH1

Stomach cancer

SOCS1, GSTP1

Liver cancer

ER, BRCA1, E-cadherin, TMS1

Breast cancer

BRCA1

Ovarian cancer

GSTP1

Prostate cancer

p16, DAPK, RASSFIA

Lung cancer

p16, TPEF/HPP1, miR-127

Bladder cancer

VHL

Kidney cancer

p15, EST1, ID4

Leukemia

p16, p73, MGMT

Lymphoma

  1. amodified from Esteller M. [15]. p16, p16INK4a; p14, p14ARF; p15, p15INK4b.