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Table 1 Overlap between regions with methylation changes in colorectal cancer with chromatin marks in ES cells

From: BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer

 

Total

SUZ12 Pa

H3K27me3P

CTCF P

H3K4me3P

Colon tumor regions

1,770

540 (30.5%) 0

561 (31.7%) 0

379 (21.4%) 0

711 (40.2%) 0.000,012

Remaining regions

30,401

3,447 (11.3%)

3,336 (11%)

10,137 (33.3%)

13,835 (45.5%)

CIMP-specific regions

749

160 (21.4%) 0

169 (22.6%) 0

183 (24.4%) 0.000,001

300 (40.1%) 0.004,6

Remaining regions

31,422

3,827 (12.2%)

3,728 (11.9%)

10,333 (32.9%)

14,246 (45.3%)

BRAF -specific regions

758

171 (22.6%) 0

180 (23.7%) 0

195 (25.7%) 0.000,035

169 (22.3%) 0

Remaining regions

31,413

3,816 (12.1%)

3,717 (11.8%)

10,321 (32.8%)

14,377 (45.8%)

  1. aP values are those for the χ-squared test.