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Table 2 The 30 most significantly associated probes in DNA from men

From: Changes in DNA methylation at the aryl hydrocarbon receptor repressor may be a new biomarker for smoking

Probe ID

Gene

Placement

Island status

Average beta values

t test

Corrected P value

    

Smoker

Nonsmoker

  

cg05575921

AHRR

Body

N shore

0.74

0.85

4.92 × 10−9

0.002

cg21161138

AHRR

Body

 

0.69

0.73

1.18 × 10−7

0.029

cg26703534

AHRR

Body

S shelf

0.64

0.69

4.72 × 10−7

0.076

cg22132788

MYO1G

Body

Island

0.94

0.88

1.19 × 10−6

0.144

cg17072268

PLD3

TSS1500

N shore

0.82

0.84

1.11 × 10−5

0.999

cg12108912

TMEM177

TSS1500

N shore

0.79

0.80

1.33 × 10−5

0.999

cg12803068

MYO1G

Body

S shore

0.83

0.76

1.61 × 10−5

0.999

cg22904815

  

N shore

0.44

0.48

1.65 × 10−5

0.999

cg25628057

ATAD3B

Body

S shore

0.87

0.88

3.04 × 10−5

0.999

cg04521543

TMEM18

3'UTR

 

0.83

0.82

3.29 × 10−5

0.999

cg11270237

  

N shore

0.34

0.36

3.61 × 10−5

0.999

cg00498653

  

Island

0.15

0.17

3.80 × 10−5

0.999

cg22537081

TBRG4

TSS200

Island

0.03

0.03

3.94 × 10−5

0.999

cg23311108

   

0.33

0.36

5.29 × 10−5

0.999

cg27312872

C1orf212

Body

N shelf

0.83

0.84

5.50 × 10−5

0.999

cg13960339

ZIM2

TSS200

Island

0.51

0.53

6.27 × 10−5

0.999

cg07918390

GPSM3

TSS1500

Island

0.04

 

6.60 × 10−5

0.999

cg16148833

   

0.72

0.74

6.85 × 10−5

0.999

cg27072683

NDUFB8

TSS1500

S shore

0.25

0.27

7.28 × 10−5

0.999

cg16579844

RNASE4

1stExon

S shore

0.04

0.04

7.54 × 10−5

0.999

cg08939942

   

0.91

0.92

7.59 × 10−5

0.999

cg25202390

MRPL30

1stExon

Island

0.18

0.16

9.23 × 10−5

0.999

cg04097463

  

S shelf

0.84

0.86

9.76 × 10−5

0.999

cg19192585

  

Island

0.03

0.03

9.78 × 10−5

0.999

cg18075691

  

N shelf

0.41

0.36

9.87 × 10−5

0.999

cg20215007

ZNF467

5'UTR

N shore

0.19

0.21

0.0002

0.999

cg11467141

  

Island

0.95

0.92

0.0002

0.999

cg00534919

C1orf26

Body

 

0.10

0.10

0.000113816

0.999

cg08771171

CTNNA1

Body

 

0.80

0.82

0.0001182

0.999

cg21029030

MIF4GD

TSS1500

Island

0.02

0.02

0.000118582

0.999

  1. All average methylation values are non-log transformed beta values. Island status refers to the position of the probe relative to the island. Classes include: 1) Island, 2) N (north) shore, 3) S (south) shore, 4) N (north shelf), 5) S (south) shelf and 6) blank, denoting that the probe does not map to an island.
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Clinical Epigenetics

ISSN: 1868-7083

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