Figure 6

Assessment of selected methylated Infinium Methylation27 probes in the Cancer Genome Atlas (TCGA) tumour and associated normal pairs. These in-scale diagrams map the position of the Infinium Methylation27 microarray probes for three of the five selected genes, GCM2, RGS7, NEFM, in relation to their CpG island and first exon(s). The probes selected for by this analysis are coloured red. For each probe there is a graph of the average β-values for both the tumour and the associated normal with the 199 tumour/associated normal TCGA samples split into those designated methylated or unmethylated. Methylated samples were defined as having an increase in β-value of 0.3 or greater within the tumour compared to the associated normal. The number and percentage of methylated and unmethylated samples are shown, with those demonstrating significant tumour-specific methylation coloured in red.