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Table 4 Delayed increase in peripheral blood cell counts for acute myeloid leukemia (AML) patients with stable disease during treatment with all-trans retinoic acid (ATRA), valproic acid and low-dose cytarabine; a comparison of pretreatment/early treatment values versus maximal levels

From: The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia

 

Platelet

Neutrophil

Erythrocyte

Patient

Before or during the first 14 days

Highest value during treatment

Before or during the first 14 days

Highest value during treatment

Transfusion independent > two months

SD1

12

49 (90)

0.1

0.7 (102)

yes

SD2

22

64 (273)

0.1

0.8 (77)

yes

SD3

< 5

79 (55)

0.4

0.4 (74)

-

SD4

103

302 (51)

0.5

0.2 (126)

-

SD5

19

51 (136)

< 0.1

0.3 (67)

yes

SD6

55

81 (106)

< 0.1

0.2 (112)

-

SD7

18

30 (15)

9.8

7.2 (27)

-

SD8

48

98 (40)

3.8

8.2 (473)

-

SD9

28

96 (141)

2.9

1.8 (49)

-

  1. The values before treatment represent the lowest value during this time. The highest value represents the value registered after the first 14 days of treatment, and the parenthesis gives the day after start of treatment when this value was registered. The units for both platelet and neutrophil counts are × 109 /L.