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Table 1 Clinicopathological and molecular data for patients analyzed by bisulfite genomic sequencing

From: Hypermethylation of the 5′ CpG island of the p14ARF flanking exon 1β in human colorectal cancer displaying a restricted pattern of p53 overexpression concomitant with increased MDM2 expression

Patient’s number Location Type of differentiation Stage MMR IHC MSI status p53 IHC TP53 mutation
1 Sigmoid Moderate IV Positive MSS D p.R248W
3 Sigmoid Moderate IIIB Positive MSS D No
11 Left Moderate IV Positive1 MSI-H D No
12 Rectum Moderate IIA Positive MSS D p.R273C
15 Sigmoid Well IV Positive MSS D p.R248Q
24 Left Moderate IIA Positive MSS D No
26 Rectum Well I Positive MSS D p.R248W
28 Rectum Moderate IV Positive MSS D No
30 Sigmoid Poor IIIB Positive MSS D p.C135R
33 Rectum Well IIA Positive MSS D No
34 Left Well IIB Positive MSS D No
35 Right Well IIA Positive MSS D p.[R158H (+)R267Q]
17 Sigmoid Well I Positive MSS D p.R248Q
2 Right Well IIA MLH1-/PMS2-† MSI-H R No
4 Right Mucinous IIIC MLH1-/PMS2-‡ MSI-H R No
5 Left Mucinous IIA MLH1-/PMS2-‡ MSI-H R No
6 Right Well IIA MSH2-/MSH6-† MSI-H R No
7 Right Poor IIA MLH-/PMS2-‡ MSI-H R No
8 Left Poor IV Positive MSS R No
9 Right Mucinous IIIB Positive MSS R No
10 Right Mucinous IIIB MLH1-/PMS2-† MSI-H R No
13 Left Well IIA Positive MSS R No
14 Left Well IV Positive MSS R No
16 Sigmoid Mucinous IIA Positive MSS R No
18 Rectum Poor IIIC MLH1-/PMS2-‡ MSI-H R No
19 Left Well I MLH1-/PMS2-† MSI-H R No
22 Right Mucinous IIIB MLH1-/PMS2-‡ MSI-H R No
23 Right Poor IIA MLH1-/PMS2-1 MSI-H R No
25 Left Mucinous IIA Positive MSS R No
29 Left Moderate IIA Positive MSS R No
20 Rectum Moderate IIA Positive MSS N No
21 Rectum Mucinous IIB Positive MSS N p.[K291X(+) H297Y]
27 Rectum Moderate IIA Positive MSS N c.672 + 1 G→A
31 Right Moderate IIIC Positive MSS N p.Q165X
32 Rectum Moderate IIIC Positive MSS N No
  1. Abbreviations: MMR, DNA mismatch repair system; MSI, microsatellite instability; MSI-H, microsatellite instability-high; MSS, microsatellite-stable; IHC, immunohistochemistry; D, diffuse pattern of p53 expression, R, restricted pattern of p53 expression, N, negative pattern of p53 expression.
  2. *MMR deficiency with unknown origin.
  3. †Lynch syndrome.
  4. ‡Sporadic MSI-H colorectal cancer with activating V600E BRAF somatic mutation, indicating MLH1 epigenetic silencing.
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Clinical Epigenetics

ISSN: 1868-7083

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