RETRACTED ARTICLE: Hypermethylation of the 5′ CpG island of the p14ARF flanking exon 1β in human colorectal cancer displaying a restricted pattern of p53 overexpression concomitant with increased MDM2 expression

Table 1 Clinicopathological and molecular data for patients analyzed by bisulfite genomic sequencing

Patient’s number	Location	Type of differentiation	Stage	MMR IHC	MSI status	p53 IHC	*TP53* mutation
1	Sigmoid	Moderate	IV	Positive	MSS	D	p.R248W
3	Sigmoid	Moderate	IIIB	Positive	MSS	D	No
11	Left	Moderate	IV	Positive1	MSI-H	D	No
12	Rectum	Moderate	IIA	Positive	MSS	D	p.R273C
15	Sigmoid	Well	IV	Positive	MSS	D	p.R248Q
24	Left	Moderate	IIA	Positive	MSS	D	No
26	Rectum	Well	I	Positive	MSS	D	p.R248W
28	Rectum	Moderate	IV	Positive	MSS	D	No
30	Sigmoid	Poor	IIIB	Positive	MSS	D	p.C135R
33	Rectum	Well	IIA	Positive	MSS	D	No
34	Left	Well	IIB	Positive	MSS	D	No
35	Right	Well	IIA	Positive	MSS	D	p.[R158H (+)R267Q]
17	Sigmoid	Well	I	Positive	MSS	D	p.R248Q
2	Right	Well	IIA	MLH1-/PMS2-†	MSI-H	R	No
4	Right	Mucinous	IIIC	MLH1-/PMS2-‡	MSI-H	R	No
5	Left	Mucinous	IIA	MLH1-/PMS2-‡	MSI-H	R	No
6	Right	Well	IIA	MSH2-/MSH6-†	MSI-H	R	No
7	Right	Poor	IIA	MLH-/PMS2-‡	MSI-H	R	No
8	Left	Poor	IV	Positive	MSS	R	No
9	Right	Mucinous	IIIB	Positive	MSS	R	No
10	Right	Mucinous	IIIB	MLH1-/PMS2-†	MSI-H	R	No
13	Left	Well	IIA	Positive	MSS	R	No
14	Left	Well	IV	Positive	MSS	R	No
16	Sigmoid	Mucinous	IIA	Positive	MSS	R	No
18	Rectum	Poor	IIIC	MLH1-/PMS2-‡	MSI-H	R	No
19	Left	Well	I	MLH1-/PMS2-†	MSI-H	R	No
22	Right	Mucinous	IIIB	MLH1-/PMS2-‡	MSI-H	R	No
23	Right	Poor	IIA	MLH1-/PMS2-1	MSI-H	R	No
25	Left	Mucinous	IIA	Positive	MSS	R	No
29	Left	Moderate	IIA	Positive	MSS	R	No
20	Rectum	Moderate	IIA	Positive	MSS	N	No
21	Rectum	Mucinous	IIB	Positive	MSS	N	p.[K291X(+) H297Y]
27	Rectum	Moderate	IIA	Positive	MSS	N	c.672 + 1 G→A
31	Right	Moderate	IIIC	Positive	MSS	N	p.Q165X
32	Rectum	Moderate	IIIC	Positive	MSS	N	No

Abbreviations: MMR, DNA mismatch repair system; MSI, microsatellite instability; MSI-H, microsatellite instability-high; MSS, microsatellite-stable; IHC, immunohistochemistry; D, diffuse pattern of p53 expression, R, restricted pattern of p53 expression, N, negative pattern of p53 expression.
*MMR deficiency with unknown origin.
†Lynch syndrome.
‡Sporadic MSI-H colorectal cancer with activating V600E BRAF somatic mutation, indicating MLH1 epigenetic silencing.

ISSN: 1868-7083