Patient’s number
|
Location
|
Type of differentiation
|
Stage
|
MMR IHC
|
MSI status
|
p53 IHC
|
TP53 mutation
|
---|
1
|
Sigmoid
|
Moderate
|
IV
|
Positive
|
MSS
|
D
|
p.R248W
|
3
|
Sigmoid
|
Moderate
|
IIIB
|
Positive
|
MSS
|
D
|
No
|
11
|
Left
|
Moderate
|
IV
|
Positive1
|
MSI-H
|
D
|
No
|
12
|
Rectum
|
Moderate
|
IIA
|
Positive
|
MSS
|
D
|
p.R273C
|
15
|
Sigmoid
|
Well
|
IV
|
Positive
|
MSS
|
D
|
p.R248Q
|
24
|
Left
|
Moderate
|
IIA
|
Positive
|
MSS
|
D
|
No
|
26
|
Rectum
|
Well
|
I
|
Positive
|
MSS
|
D
|
p.R248W
|
28
|
Rectum
|
Moderate
|
IV
|
Positive
|
MSS
|
D
|
No
|
30
|
Sigmoid
|
Poor
|
IIIB
|
Positive
|
MSS
|
D
|
p.C135R
|
33
|
Rectum
|
Well
|
IIA
|
Positive
|
MSS
|
D
|
No
|
34
|
Left
|
Well
|
IIB
|
Positive
|
MSS
|
D
|
No
|
35
|
Right
|
Well
|
IIA
|
Positive
|
MSS
|
D
|
p.[R158H (+)R267Q]
|
17
|
Sigmoid
|
Well
|
I
|
Positive
|
MSS
|
D
|
p.R248Q
|
2
|
Right
|
Well
|
IIA
|
MLH1-/PMS2-†
|
MSI-H
|
R
|
No
|
4
|
Right
|
Mucinous
|
IIIC
|
MLH1-/PMS2-‡
|
MSI-H
|
R
|
No
|
5
|
Left
|
Mucinous
|
IIA
|
MLH1-/PMS2-‡
|
MSI-H
|
R
|
No
|
6
|
Right
|
Well
|
IIA
|
MSH2-/MSH6-†
|
MSI-H
|
R
|
No
|
7
|
Right
|
Poor
|
IIA
|
MLH-/PMS2-‡
|
MSI-H
|
R
|
No
|
8
|
Left
|
Poor
|
IV
|
Positive
|
MSS
|
R
|
No
|
9
|
Right
|
Mucinous
|
IIIB
|
Positive
|
MSS
|
R
|
No
|
10
|
Right
|
Mucinous
|
IIIB
|
MLH1-/PMS2-†
|
MSI-H
|
R
|
No
|
13
|
Left
|
Well
|
IIA
|
Positive
|
MSS
|
R
|
No
|
14
|
Left
|
Well
|
IV
|
Positive
|
MSS
|
R
|
No
|
16
|
Sigmoid
|
Mucinous
|
IIA
|
Positive
|
MSS
|
R
|
No
|
18
|
Rectum
|
Poor
|
IIIC
|
MLH1-/PMS2-‡
|
MSI-H
|
R
|
No
|
19
|
Left
|
Well
|
I
|
MLH1-/PMS2-†
|
MSI-H
|
R
|
No
|
22
|
Right
|
Mucinous
|
IIIB
|
MLH1-/PMS2-‡
|
MSI-H
|
R
|
No
|
23
|
Right
|
Poor
|
IIA
|
MLH1-/PMS2-1
|
MSI-H
|
R
|
No
|
25
|
Left
|
Mucinous
|
IIA
|
Positive
|
MSS
|
R
|
No
|
29
|
Left
|
Moderate
|
IIA
|
Positive
|
MSS
|
R
|
No
|
20
|
Rectum
|
Moderate
|
IIA
|
Positive
|
MSS
|
N
|
No
|
21
|
Rectum
|
Mucinous
|
IIB
|
Positive
|
MSS
|
N
|
p.[K291X(+) H297Y]
|
27
|
Rectum
|
Moderate
|
IIA
|
Positive
|
MSS
|
N
|
c.672 + 1 G→A
|
31
|
Right
|
Moderate
|
IIIC
|
Positive
|
MSS
|
N
|
p.Q165X
|
32
|
Rectum
|
Moderate
|
IIIC
|
Positive
|
MSS
|
N
|
No
|
- Abbreviations: MMR, DNA mismatch repair system; MSI, microsatellite instability; MSI-H, microsatellite instability-high; MSS, microsatellite-stable; IHC, immunohistochemistry; D, diffuse pattern of p53 expression, R, restricted pattern of p53 expression, N, negative pattern of p53 expression.
- *MMR deficiency with unknown origin.
- †Lynch syndrome.
- ‡Sporadic MSI-H colorectal cancer with activating V600E BRAF somatic mutation, indicating MLH1 epigenetic silencing.