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Figure 2 | Clinical Epigenetics

Figure 2

From: On the epigenetics of vascular regulation and disease

Figure 2

Epigenetic modulation of Eotaxin expression via NFκ-B. Inflammatory signalling via TNF-α leads to acetylation of histone H4 and induces the binding of p65 subunit of NFκB-complex to unmethylated sites of the eotaxin promoter. Transcription of the eotaxin gene is induced and consequently the number of inflammatory cells which are recruited and activated within the atherosclerotic plaque.

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