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Figure 4 | Clinical Epigenetics

Figure 4

From: A macroepigenetic approach to identify factors responsible for the autism epidemic in the United States

Figure 4

Methionine synthase links oxidative stress to epigenetic regulation. Figure 4 shows how exposure to toxic substances, such as OP pesticides, HFCS, or heavy metals, inhibits methionine synthase through effects of oxidative stress. As a result, decrease of SAM to SAH ratio will lead to a decrease in DNA methylation and consequently to altered PON1 gene expression.

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