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Figure 2 | Clinical Epigenetics

Figure 2

From: Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

Figure 2

Model for the regulation of HDAC1-HDAC2 complex formation by phosphorylation. When phosphorylated by CK2, HDAC2 binds to the core components of Sin3, NuRD and CoREST complexes as homodimer or heterodimer with HDAC1. In the low or unphosphorylated states, HDAC1 and HDAC2 bind to proteins such as the serine/arginine (SR)-rich proteins and RNA-binding protein Hu antigen R (HuR/ELAVL1) which interact with the spliceosome.

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Clinical Epigenetics

ISSN: 1868-7083

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